A Case of Generalized Plane Xanthoma Associated with Multiple Myeloma and Hyperlipoproteinemia / 대한피부과학회지

Generalized plane xanthoma is a group of plane xanthomas that appear as yellow to yellow-brown flat patches or slightly elevated plaques with a wide-spread distribution. The disease is frequently associated with multiple myeloma or other reticulo-endothelial malignancies and monoclonal gammopathy with unknown significance, and when accompanied by these hematologic malignancies, normolipoproteinemia is invariably associated. We present a case of generalized plane xanthoma associated with multiple myeloma and type III hyperlipoproteinemia in a 48 year-old woman, and this is the first report in Korean literature.

Four Cases of Papillomatous Melanocytic Nevus Mimicking Seborrheic Keratosis / 대한피부과학회지

Papillomatous melanocytic nevus is a clinical type of melanocytic nevus, which show a resemblance to seborrheic keratoses both clinically and histopathologically. Therefore, this kind of nevi is also described by the terms of keratotic melanocytic nevus and seborrheic wart-like melanocytic nevus. Characteristic histopathologic findings include epidermal acanthosis, hyperkeratosis, papillomatosis, a lacelike and downward growth of epidermal strands, and horn cysts. We present four cases of papillomatous melanocytic nevi in 3 females and 1 male patients, which did not express estrogen receptors in immunohistochemical study.

A Case of Myoepithelial Carcinoma of Minor Salivary Gland / 대한피부과학회지

Myoepithelial carcinomas are rare, malignant salivary neoplasms in which the tumor cells almost exclusively manifest myoepithelial differentiation. A 50-year-old man presented with an indolent movable submucosal mass of 10 years' duration on the right upper oral mucosa. The diagnosis of myoepithelial carcinoma originated from minor salivary gland was made by histopathologic and immunohistochemical evaluation.

A Case of Eosinophilic Folliculitis after Allogenic Bone Marrow Transplantatino in Acute Myelogenous Leukemia

Eosinophilic folliculitis (EF) is regarded as a variant of eosinophilic pustular folliculitis (EPF), because it has a few distinctive clinical features different from those of EPF. EF is generally associated with systemic disorders, such as acquired immunodeficiency syndrome (AIDS) and hematologic malignancies. We have recently experienced a case of EF occurring in a 40 year-old male patient treated with allogenic bone marrow transplantation (BMT) for acute myelogenous leukemia(AML) and achieved a good clinical outcome after a short course of systemic corticosteroid therapy. The immunologic aberration resulting from systemic diseases may play a role in the development of EF.

A Case of Motor Paralysis of the Limb caused by Herpes Zoster

Segmentally distributed cutaneous eruptions and neuralgia are common manifestations of herpes zoster. However, motor loss is another aspect of this manifestation, which is less well known and considered a rare finding. In many cases the loss of motor function may be easily overlooked because the pain is the more prominent feature and the weakness probably goes unrecognized with only a mild impairment of the motor function. We experienced a 71-year-old male patient with a herpes zoster-related motor paralysis of right arm whose clinical features of a weak limb mimicked other spinal motor diseases and confirmed motor involvement using electromyographic (EMG) and motor nerve conduction velocity (MNCV) studies.

Clinical Experiences of Photodynamic Therapy in the Extramammary Paget's Disease / 대한피부과학회지

BACKGROUND: Photodynamic therapy(PDT) is a kind of non-invasive photochemotherapy, which is designed to kill the target cells through photodynamic reaction. It has been reported that PDT is very effective in superficial lesions, including extramammary Paget's disease. Yet, there has been no clinical trial for the treatment of extramammary Paget's disease using PDT in Korea. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of PDT in treating extramammary Paget's disease METHOD: Seven patients with anogenital extramammary Paget's disease were treated repeatedly with local PDT using topical ALA 20% and intralesional injection of hematoporphyrin derivative (HpD), and systemic PDT using HpD. Fluences of 125-200J/cm2 and intensities of 50-100mW/cm2 were used. RESULT: The clinical outcomes were disappointing. All the patients experienced only partial responses despite repeated treatments. But side effects were minimal. CONCLUSION: PDT is not effective enough for the treatment of extramammary Paget's disease to be used as a primary therapy. It would be better to use as an adjuvant to other treatment methods. Photodynamic sensitization, also known as photodynamic diagnosis, might help us define a more reliable border of the extent involved and the surgical margin to be excised.

Clinical Experiences of Photodynamic Therapy in the Extramammary Paget's Disease / 대한피부과학회지

BACKGROUND: Photodynamic therapy(PDT) is a kind of non-invasive photochemotherapy, which is designed to kill the target cells through photodynamic reaction. It has been reported that PDT is very effective in superficial lesions, including extramammary Paget's disease. Yet, there has been no clinical trial for the treatment of extramammary Paget's disease using PDT in Korea. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of PDT in treating extramammary Paget's disease METHOD: Seven patients with anogenital extramammary Paget's disease were treated repeatedly with local PDT using topical ALA 20% and intralesional injection of hematoporphyrin derivative (HpD), and systemic PDT using HpD. Fluences of 125-200J/cm2 and intensities of 50-100mW/cm2 were used. RESULT: The clinical outcomes were disappointing. All the patients experienced only partial responses despite repeated treatments. But side effects were minimal. CONCLUSION: PDT is not effective enough for the treatment of extramammary Paget's disease to be used as a primary therapy. It would be better to use as an adjuvant to other treatment methods. Photodynamic sensitization, also known as photodynamic diagnosis, might help us define a more reliable border of the extent involved and the surgical margin to be excised.

A case of Unilateral Demodectic Rosacea / 대한피부과학회지

Rosacea is a chronic and recurrent inflammatory eruption of the flush areas of the face, particularly the nose, which is characterized by erythema, papules, pustules, and telangiectasia. Although the precise etiology remains as a mystery, various factors including genetic disposition, vascular dysfunction, solar elastotic degeneration, gastrointestinal disturbance, hormonal influences, increased humoral vasoactive mediators, and Demodex folliculorum infestation have been suspected of contributing to this condition. In recent study, it has been reported that a high density of Demodex folliculorum may have a pathogenic role in rosacea, especially in the development of inflammatory lesions. We report an unilateral rosacea-like chronic dermatitis of the left side of the face which was shown to harbor many Demodex folliculorum mites.

Two cases of surgically treated extramammary Paget's disease guided by photodynamic diagnosis / 대한피부과학회지

Extramammary Paget's disease is a rare malignancy occuring mainly in apocrine gland- bearing areas such as vulva, scrotum, perianal area, and axilla. Histopathologically, the Paget's cells are usually confined within the epidermis and may be associated with underlying adenocarcinoma. Although surgical excision is the treatment of choice, the clinical demarcation of the lesion is still a frequent problem in the treatment of extramammary Paget's disease. We tried photodynamic diagnosis to determine the surgical margin of extramammary Paget's disease and with surgical excision guided by photodynamic diagnosis successfully treated two cases.

A Case of Labial Mucosal Melanoma Metastasized to the Lung / 대한피부과학회지

Mucosal melanoma is rare compared with its cutaneous counterpart. Mucosal melanomas can occur in any mucosa such as the mouth, anus, vagina, nose, larynx, conjunctiva, and sinus. In the oral cavity, hard palate, maxillary aveolus, soft palate, tongue and the floor of mouth are common sites for mucosal melanoma. It shows poor prognosis because the local recurrence and distant metastasis to other organs are common. We present a case of labial mucosal melanoma developed in 61-year-old male patient which metastasized to the lung and was confirmed by CT-guided lung biopsy.