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Indian J Biochem Biophys ; 2012 Jun; 49(3): 165-172
Artículo en Inglés | IMSEAR | ID: sea-140232

RESUMEN

Generally, extra-cellular-signal-regulated kinase 5 (ERK5) signaling pathway regulates many physiological activities, such as cell proliferation and cell differentiation. However, little is known about how ERK5 signaling pathway composed of 15 paths participates in regulating hepatocyte proliferation during liver regeneration (LR). In this study, to explore the influence ERK5 signaling pathway upon hepatocytes at gene transcription level, rat genome 230 2.0 array was used to detect expression changes of 75 related genes in isolated hepatocytes from rat regenerating liver. Bioinformatics and systems biology methods were applied to analyze the precise role of ERK5 signaling pathway in regulating hepatocyte proliferation during LR. Results showed that 62 genes were contained in the array and 22 genes were significantly changed. It was found that 6 paths were related to hepatocyte proliferation during rat LR. Among them, paths 3, 6 and 13 of ERK5 signaling pathway modulated cell cycle progression by decreasing the negative influence on ERK5 and paths 3, 4, 8 and 9 by reinforcing the positive influence on ERK5. In summary, the study shows that 22 genes and 6 paths of ERK5 signaling pathway participate in regulating proliferation of hepatocytes in rat LR.


Asunto(s)
Animales , Procesos de Crecimiento Celular/genética , Procesos de Crecimiento Celular/fisiología , Perfilación de la Expresión Génica/métodos , Hepatectomía , Hepatocitos/citología , Hepatocitos/enzimología , Hepatocitos/fisiología , Regeneración Hepática/genética , Regeneración Hepática/fisiología , Sistema de Señalización de MAP Quinasas/genética , Sistema de Señalización de MAP Quinasas/fisiología , Proteína Quinasa 7 Activada por Mitógenos/genética , Proteína Quinasa 7 Activada por Mitógenos/metabolismo , Análisis de Secuencia por Matrices de Oligonucleótidos/métodos , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley
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