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Journal of Forensic Medicine ; (6): 188-190, 2015.
Artículo en Chino | WPRIM | ID: wpr-983985

RESUMEN

OBJECTIVE@#To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.@*METHODS@#The CD63 expression of basophilic granulocyte in blood was detected by flow cytometry. The levels of MC-CPA3 in blood serum and SC5b-9 in blood plasma were detected by ELISA.@*RESULTS@#The CD63 expression of basophilic granulocyte in blood, the levels of MC-CPA3 and SC5b-9 of anaphylaxis to non-ionic contrast media and β-lactam drugs were significantly higher than that in normal immune group (P < 0.05).@*CONCLUSION@#There is activation of basophilic granulocytes, mast cells and complement system in anaphylaxis to non-ionic contrast media. BAT can be used to diagnose the anaphylaxis to non-ionic contrast media.


Asunto(s)
Humanos , Anafilaxia/diagnóstico , Basófilos/citología , Carboxipeptidasas A/metabolismo , Complejo de Ataque a Membrana del Sistema Complemento/metabolismo , Medios de Contraste , Citometría de Flujo , Granulocitos/citología , Mastocitos/citología , Tetraspanina 30/metabolismo
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