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Although great progress has been made in perinatal and neonatal medicine, the morbidity and mortality of premature complications remain high.At present, the prevention and treatment of preterm infants with broncho-pulmonary dysplasia, brain injury, necrotizing enterocolitis, retinopathy of prematurity and other complications are cha-llenging.Experimental evidences have shown that regenerative medicine based on mesenchymal stem cells is a promising therapeutic strategy for premature complications, although it has potential risks like tumorigenicity and immune rejection.Exosomes are the key mediators of mesenchymal stem cells, which have been a promising method for the treatment of premature complications.This study aims to review the research progress of exosomes derived from mesenchymal stem cells in the treatment of premature complications.
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Antenatal corticosteroid administration to women at risk of preterm delivery within 34 gestational weeks can effectively reduce the incidence of respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis in preterm infants. Due to concerns that antenatal corticosteroids may impair the development of the newborn's nervous system, there is a controversy regarding the use of antenatal corticosteroids in pregnant women ≥34 gestational weeks and those with complications. This article reviews the short- and long-term effects of antenatal corticosteroid administration on the nervous system of neonates born to women at different gestational ages and with comorbidities. More and higher-quality evidence is required for routine application of antenatal corticosteroids in pregnant women ≥34 gestational weeks.
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Nasal continuous positive airway pressure (nCPAP) has been widely used in neonatal respiratory support,but how to successfully withdraw nCPAP has not been further studied,and there is no unified standard of timing and mode of nCPAP weaning.This paper reviews the research progress of nCPAP weaning in premature infants.
RESUMEN
Nasal continuous positive airway pressure (nCPAP) has been widely used in neonatal respiratory support, but how to successfully withdraw nCPAP has not been further studied, and there is no unified standard of timing and mode of nCPAP weaning.This paper reviews the research progress of nCPAP weaning in premature infants.
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<p><b>OBJECTIVE</b>To detect mutations of the retinitis pigmentosa GTPase regulator (RPGR) gene in two Chinese X-linked retinitis pigmentosa families.</p><p><b>METHODS</b>Fragments of exons 1-19 of the RPGR gene were amplified with intronic primers, using genomic DNA as template. The polymerase chain reaction (PCR) products were analysed by single-strand conformation polymorphism (SSCP) and direct sequencing. Mutations were identified by comparing DNA sequences of the patients with those of the normal controls.</p><p><b>RESULTS</b>Two novel mutations, c1536delC and E332X, were identified in exons 12 and 9 of the RPGR gene in both families. Each mutation was the first mutation found in their respective exons. Both mutations were predicted to cause premature termination, which resulted in truncated proteins without normal functions of the RPGR products.</p><p><b>CONCLUSIONS</b>Both mutations are the genetic basis of the pathogenesis in the respective families. Our data might be helpful in analysing the function of the RPGR protein.</p>
Asunto(s)
Femenino , Humanos , Masculino , Proteínas Portadoras , Genética , Proteínas del Ojo , Ligamiento Genético , Mutación , Reacción en Cadena de la Polimerasa , Polimorfismo Conformacional Retorcido-Simple , Retinitis Pigmentosa , Genética , Análisis de Secuencia de ADN , Cromosoma XRESUMEN
Static database can not meet the requirement of web development. The dynamic database which is based on the dynamic memory and management technologies has become the preferred choice. This paper compares five primary methods for web database access, and an example is given to illustrate how ASP.NET access SQL server.