Study on the effect of different polymers on in-vitro dissolution profile of Fenofibrate by solid dispersion technique.

Fenofibrate is a poor water soluble drug having poor rate of dissolution. In this research work we tried to enhance dissolution of fenofibrate by following solid dispersion of fenofibrate formulations with different dissolution enhancing polymers likeHPMC 6cps, Poloxamer 188, Poloxamer 407, PEG 6000. Total twenty four formulations were prepared with this polymers in single or combinations. If the solid dispersion is first, other parameters like dissolution, bioavailability will be first. Dissolution of all the formulations were tested for % drug release profile, mean dissolution time, assay and uniformity of drug content and % recovery was calculated. From all formulations, F3, F5, F6, F9, F10, F12 and F14 shows greater dissolution of fenofibrate 93.64%, 83.66%, 100.53%, 100.61%, 100.95% and 83.06% respectively within 60 minutes of dissolution and also decreases the mean dissolution time. Based on in-vitro dissolution results and drug release model kinetics, we can decide that these formulations are able to increase the dissolution as well as can increase the absorption rate and bioavailability of fenofibrate. Finally we can conclude that, these formulations enhance the dissolution and bioavailability of Fenofibrate and good formulation candidates for Fenofibrate in future.

study on cases attending physical medicine, rehabilitation and rheumatology outpatient clinic [for children] in national institute of neuromotor rehabilitation

Different diseases are seen in physical medicine, rehabilitation and rheumatology out patient clinic [for children] in national institute of neuromotor rehabilitation. To know various diseases attending this clinic in one year [2007]. -To know the commonest diseases. -To provide the institute with various types of investigation for these patients [haematological, radiological, neurophysiological, etc....] -To provide these patients with various types of treatment [Medical, physical, and surgical] and devices needed for these patients. 3611 patients attending physical medicine outpatient clinic [for children] in one year [2007] till 12 years old. To know different types of diseases attending this clinic: -Disease history - Clinical examination - Investigation: hematological, Radiological, neurophysiolgical, etc... To know number of cases of each disease and the commonest diseases. Disease: U.M.N.L, Deformities, L.M.N.L., Post operative, Chronic poliomyelitis, Others, Sum. No. of cases: 2072, 446, 284, 146, 51, 613, 3611. Percentage%: 57.38%, 12.32%, 7.86%, 4.04%, 1.41%, 100%. -The commonest diseases attending physical medicine out patient clinic [for children] in national institute of neuromotor rehabilitation: U.M.N.L followed by deformities. -The institute must be provided with investigation for these diseases [haematological, radiological, neurophysiological etc...] different types of treatment [Medical, physical and surgical] and with equipment and devices