RESUMEN
Total of 3822 cases of meningitis were reported to the central laboratories of Kalyobia Governorate [Egypt] from the first of January 1984 to the end of December 1996. The main trend of the disease showed peak incidence in the period from 1989 to 1991 [Epidemic wave]. Haemophilus influenzae [35.04%] and Nesseria meningitidis [24.23%] were the most common bacterial agents diagnosed. Meningococcal meningitis was mostly caused by group A [30.24%] and group B [13.17%] allover the period of the study, while other new groups were diagnosed during the epidemic period [CD, W 135, Y and Z], the later showed high frequency [28.94%]. 11.30% of the cases had purulent meningitis but without detectable aetiology owing to the early use of antibiotics. A govemomental fever hospital taken as a sample model, high frequency of cases was below 15 years with 1.22 male to female ratio, but epidemic period showed increase in the female frequency. Meningococci were the responsible agent during the epidemic and responsible for 23.07% of all the hospital mortalities. The highest case fatality rate was in the preepidemic period [15.7%]. From this study it is recommended to establish a preventive program aiming at reducing the disease incidence, morbidity and mortality through: increasing the immunization coverage, improve the vaccine quality, disease surveillance and proper management of the diagnosed cases