Prevention of ototoxicity of some commonly used drugs. Histopathological study in guinea pigs

This study was done to evaluate the efficacy of the iron-chelator deferoxamine [DFO] to attenuate the ototoxicity induced by aminoglycosides and cisplatin, respectively. It was carried out on 50 healthy pigmented guinea pigs divided into two groups. The results have revealed that there was a prominent damage in the outer hair cells, stria vascularis, myelinated nerve fiber and ganglion cells and that DFO ameliorates these degeneration processes which resulted from GM and cisplatin administration, respectively