RESUMEN
OBJECTIVE: Investigate different intestinal segments absorption of salvianolic acids and compatibility of different concentration of sodium caprate in rats. METHODS: Using single-pass intestinal perfusion model, three concentrations of lithospermic acid, rosmarinic acid and salvianolic acid B was determined by HPLC, and the intestinal absorption parameters of Ka and Papp was calculated. RESULTS: When salvianolic acids concentrion was 800 μg·mL-1 salvianolic acids concentration, absorption of lithospermic acid of various intestinal segments: duodenum≈jejunum>ileum; absorption of rosmarinic acid; ileum>jejunum>duodenum; absorption of salvianolic acid B: ileum>jejunum≈duodenum. After salvianolic acids combined with different concentrations of sodium caprate, low concentration of sodium caprate slightly inhibited the lithospermic acid and salvianolic acid B uptake, middle and high concentration sodium caprate were able to better promote salvianolic acids intestinal absorption. CONCLUSION: Sodium caprate can promote intestinal absorption of salvianolic acids. With sodium caprate concentration increasing, absorption enhancing effect is more significant.