A Case of Invasive Squamous Cell Carcinoma of the Vulva / 대한피부과학회지

Vulvar cancer is uncommon and represents about 4% of malignancies of the female genital tract. Squamous cell carcinomas account for about 90% of the cases. However few cases are reported in dermatologic literatures. Theses lesions are usually characterized by firm, hyperkeratotic papules, plaques or indurated erosions. Human papilloma virus(HPV)DNA has been reported in 20-60% of patients with invasive vulvar cancer. The HPV-positive group has been characterized by a younger mean age, more tobacco use, and simultaneous presence of vulvar intraepitherial neoplasia(VIN) and the invasive component. We report a case of invasive squamous cell carcinoma of the vulva associated with HPV type 16 positive according to polymerase chain reaction.