1.
Journal of Zhejiang University. Medical sciences
;
(6): 581-585, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-336748
RESUMEN
The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.