RESUMEN
A [cocktail] of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was aimed on the influence of bupropion on cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutamide administered either separately or in combined with bupropion were compared in this study. The results revealed that bupropion had no significant effect on tolbutamide hydroxylation. Thus, due to stability in cytochrome P450 enzyme metabolic activity in the case of combining of two model probe drugs the procedure can show to no extent differential results comparing to the single-marker use
RESUMEN
A preliminary survey was done in 1980 in Jijiaba Village before the dike was built . The dike of 2. 5 km in length and 4m high was built along Baiyang River by the end of 1980 . The molluscicide NaPCP was used for snail control from 1981 to 1984 . After the entire control measures were completed in 1984, a follow-up survey was conducted as to measure the impact of control measures on prevalence of schistosomiasis and population of snail from 1985 to 1989 . All of the results suggested that these control measures were very successful. The transmission of schistosomiasis in this area has been prevented since 1984 .
RESUMEN
A 4-year study on the factors affecting the prevalenee and epidemiological pattern of schistosomiasis japonica around Dongtin and Boyang lakes was reported. A proposal was made on the division of the endemic areas of the lake and marshland regions into different types,a definition about the high-risk places and the principles of their classification.This study also elucidated the main reservoirs of different types of endemic areas and the relationship between human exposure and infection. On the basis of the effects of prevention and treatment and cost-effect analysis in the 8 field study units, the goal for the control of schistosomiasis in the lake region for the next 3~5 years has been devised.A preliminary mathematical model of human and domestic animals as the main reservoirs of infection has been set up.
RESUMEN
A quantitative study on human water contact was carried out in an endemic area of schistosomiasis japonica. The information relating to frequency, duration and intensity of each activities was obtained from 390 persons (93% of all) aged 5-59 and 10 days of each season in 1987 was surveyed by using systematic sampling. Socioeconomic investigation and stool examination were also performed on the same population. It is found that cutting grass and fishing are the most important activities, as well as swimming and bathing. The accumulated index ofexposure is high in spring and summer, low in autumn and rare in winter. The peak contact is 8-12 o'clock in the morning. The reasons of contact are different between males and females. And the peak contact is at teen aged youth. Studies on water contact and socioeconomic factors show that there are more contacts in peasants than in those with other occupations. Rich farmers who has more savings contact less. The contacts seem more frequent in those whose family water supply is from infected water. The stepwise regression analysis shows that the most important factor relating to the infection of schistosomiasis japonica are index B of exposure (accumulation of duration ? intensity). The infected water supply of family and education were two other factors relating to the infection.
RESUMEN
Ninety two male mouse (weight 22?3g) were randomly divided into test and control groups Vitamin E and rqual volume excipient were given i. m. respectively. The concentration of vitamin E in serum of test group was twice as thatof control group. These two groups were compressed simultaneously to 14kgf/cm2 with compressed air at the rate of 2kgf/cm2 per minute for 50 minutes, anddccompressed to surface in 7 minutes. The results showed : the morbidity of serious ease and the mortality in test group were lower than that in the control group, and the reduction of circulating platelct number is less than that in control group. These results suggested that vitamin E has protective effects on mice decompression sickness.