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Objective: Acute pancreatitis(AP) often impairs peripancreatic tissues and involves more distant organs,such as the liver,which would exacerbate the progression of the disease.This study aimed to explore the clinical characteristics of acute pancreatitis-associated liver injury.Methods: We randomly retrieved 156 cases of AP from the medical records retrieval system of Jinling Hospital,of which 102 were complicated by liver injury.The latter were divided into a severe AP(n=44) and a mild AP group(n=58) for comparative analysis of the severity of liver injury and time of recovery.Results: Liver injury occurred in 65.38% of the AP patients,and it was more serious,had a longer disease course and took more time to recover in the severe than in the mild AP group.Conclusion: The incidence and severity of acute pancreatitis-associated liver injury are positively correlated with the severity of acute pancreatitis.
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Angiotensin-converting-enzyme inhibitors(ACEI) are generally used in the treatment of cardiovascular system diseases.They are found by epidemiological studies to have an anti-tumor activity and are shown to play various roles in suppressing carcinogenesis and tumor growth,preventing angiogenesis,inhibiting matrix degradation and reducing cancer cachexia.
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Objective To evaluate the protective effect of Caspase-1 inhibitor on acute lung injury(ALI) induced by experimental severe acute pancreatitis(SAP).Methods Forty-two SD rats were randomly assigned into 3 groups: healthy controls group(HC,n=6),SAP+normal saline group(SAP-S,n=18) and SAP+ICE inhibitor group(SAP-ICE-I,n=18).SAP was reproduced by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct in SD rats.In animals in HC group same surgical procedure and duct cannulation were performed but without introduction of sodium taurocholate.In SAP-S group,rats received the first intraperitoneal injection of isotonic saline 2h after induction of acute pancreatitis,and the injection of saline was repeated at the 12th hour after induction.In SAP-ICE-I group,rats were given ICE inhibitor intraperitoneally 2h after induction of pancreatitis.Surviving rats were sacrificed at designated time points,and blood and all organs were obtained for subsequent analysis.Serum IL-1? was measured by ELISA.Intrapulmonary expressions of Caspase-1,IL-1? and IL-18 mRNA were detected by semi-quantitative RT-PCR.The ratios of wet/dry weight and histopathological changes in lung were also evaluated.Results The serum IL-1? levels in SAP-S group were 276.77?44.92pg/ml at 6h,308.99?34.95pg/ml at 12h and 311.60?46.51pg/ml at 18h after induction of SAP,respectively,which were increased significantly compared with that in HC group(P0.05).The wet/dry weight ratio of lung in SAP-S group was increased significantly compared with that in HC group(P
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Objective:To evaluate the effects of losartan、fosinopril and captopril on the excretion rate of urinary albumin (UAER) and the clearance of endogenous creatinine (Cr-C) in elderly patients. Methods:In this study,162 elderly patients with stage of the 2—3 class hypertension were included,The patients were divided into 3 groups,that were losartan group and the fosinopril group and captopril group,the anti-hypertensive effects and UAER and Cr-C were determined before and after the treatment. Results:The hypertensive effect rates were 94% in losartan group and 93%、93% in fosinopril group and captopril group respectively.Decrease of UAER was observed in 89% of patient in losartan group and 59%、50% in fosinopril group、captopril group.Cr-C were improved in 94%、78% of patient in losartan group and in fosinopril group and 63% in captopril group. Conclusions:Losartan has better effects on UAER and Cr-C than captopril in elderly hypertensive patients.