RESUMEN
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Asunto(s)
Animales , Humanos , Ratones , Antineoplásicos Fitogénicos , Química , Farmacología , Línea Celular Tumoral , Cristalografía por Rayos X , Diterpenos de Tipo Kaurano , Química , Farmacología , Ensayos de Selección de Medicamentos Antitumorales , Medicamentos Herbarios Chinos , Química , Farmacología , Células HL-60 , Isodon , Química , Lipopolisacáridos , Farmacología , Macrófagos , Estructura Molecular , Óxido Nítrico , Resonancia Magnética Nuclear Biomolecular , Componentes Aéreos de las Plantas , QuímicaRESUMEN
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.