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Objective To investigate the optimal scan time of MRI using the imaging probe alphamethyl-L-tryptophan(α-MTrp)-superparamagnetic iron oxide nanoparticles (SPIONs) for localizing temporal lobe epilepsy (TLE) foci.Methods α-MTrp-SPIONs were injected into rat models of TLE through the tail vein during the acute and chronic stages (72 h and 8 weeks after status epilepticus,respectively).MRI was performed before and 1,2,4,8,24 h after the injection in all animals,and the T2 values of the epileptogenic regions were measured.One-way repeated measures analysis of variance was used for data analysis.Results Compared with the T2 values before the injection of α-MTrp-SPIONs,the T2 signal of epileptogenic regions after the injection had a negative increased change.The T2 values before and 1,2,4,8,24 h after the injection in acute stage were 112.08±5.85,107.83±6.59,105.08±6.79,95.58±5.14,100.92± 5.81,105.17±6.31 respectively,and those in chronic stage were 112.08±7.53,107.75±7.10,102.75± 5.50,96.17±5.01,97.75±4.37,102.92±4.74.The T2 values after the injection were significantly different from those before the injection (both P＜0.01).The T2 value at 4 h after the injection decreased mostly.Conclusions α-MTrp-SPIONs can precisely localize epileptogenic regions of TLE on MRI.The optimal scan time is 4 h after the injection.
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Objective To analyze the correlation between the early sacroiliitis in ankylosing spondylitis(AS) and clinical and laboratory parameters.Methods 39 patients with AS corresponding to the modified New York criteria for AS(0-Ⅲ)were included.According to pain score(BASDAI),the patients were divided into three groups,that were static group,suspicious active group and active group.The patients were examined by MRI and laboratory including erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP).The severity of activity of sacroiliac joint(SIJ) inflammation was evaluated using spondyloarthritis research consortium of Canada(SPARCC)score,comparative analysis was done among these three groups.Results There was significant differences among these three groups in SPARCC score(P0.05).The spearman correlation coefficient between SPARCC score and BASDAI score was rs=0.503,P0.05.Conclusion In early sacroiliitis of AS,the SPARCC score of SIJ lesions is positively correlated with the severity of BASDAI,but there is no correlation between the SPARCC score and ESR,CRP.