The effect of endotoxin on experimental hepatic insufficiency / 中国病理生理杂志

The effect of E. coli endotoxin (LPS) on early and advanced experimental cirrhosis have been studied. Results indicate that LPS has exhibited a significant promoting effect on liver damage and fibrosis, exerted inhibitory effect on colcollagen resorption. The rats with early and advanced cirrhosis were administered with LPS. Their parenchymal cells of the liver had more prominent lesion than those of the controls. The experiments demgnstrated that the hepatic renal dysfunction, hepatic encephalopathy, hilirubin metabolic disorder of the cirrhotic rats were induced and aggravated by LPS. Thus it proved that LPS is an importent pathogenic factor in the development and progress of hepatie insufficiency.