The Effects of Early Treatment of Aminophyllin on Renal Function in Neonates With Perinatal Asphyxia / 医学研究杂志

Objective To study whether early treatment of aminophylline can protect renal function in neonates with perinatal asphyxia.Methods 60 neonates with perinatal asphyxia were randomly divided into 2 groups.Within the first hour after birth,the treatment group(30 cases)received intravenously a single dose of aminophylline(5mg/kg),and the control group(30 cases)received placebo of water.Urinary Nacety-?-D-Amino-Glucosidase(NAG)activity was recorded everyday during the first 3 days of life.Heart rate,respiratory rate and blood pressure were recorded per 4h.Results Urinary NAG activity of treatment group at 48h and 72h after birth were significantly lower than that of control group(P