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According to the collection principles and characteristics of the pulse physiological signals of traditional Chinese medicine, combined with the international standard requirements of the pulse graph force transducer (ISO 19614:2017-05), a special force sensor component that can be used for a complete and objective collection of pulse signals has been developed, this sensor meets the requirements of industrialization. The sensor can measure the pulse amplitude and width signals of the cunpart of the human body. In addition, three sensors can be placed at the cun, guan, chi part at the same time, so that the "three body parts and nine pulse-taking sites" can be realized synchronously. After the sensor has been verified, the results meet the relevant requirements of international standard. The consistency of the result can be reached to 92.3% compared with the diagnosis result of clinical TCM experts.
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Humanos , Frecuencia Cardíaca , Medicina Tradicional China , Pulso Arterial , TransductoresRESUMEN
Objective@#To observe the expression of microRNA-125b (miR-125), tumor necrosis factor alpha (TNF-α) and interleukin-6(IL-6) in premature rats exposed to hyperoxia.@*Methods@#Eighty 1-day old Sprague Dawley (SD) rats were randomly divided into an air group and a hyperoxia group.The rats in the hyperoxia group were continuously exposed to oxygen chamber for 1-3 L/min, oxygen volume fraction was maintained at (800±50) mL/L, and the rats in air group were placed in the same room with the oxygen volume fraction at 210 mL/L.The feeding conditions were same in 2 groups.Lung tissues of premature rats were extracted at different time (1, 4, 7, 10, 14 days). The pathologic changes in the lung tissues were observed by hematoxylin-eosin (HE) staining.The levels of miR-125b and TNF-α, IL-6 in lung tissues were detected by reverse transcription polymerase chain reaction (qRT-PCT) and enzyme-linked immunosorbent assay (ELISA).@*Results@#Compared with the air group, miR-125b in the hyperoxia group increased slowly after day 1, reached the highest in day 10 (2.554±0.323), and the relative expression in day 14 decreased slightly(2.329±0.263), and there were significant differences between 2 groups at di-fferent time (all P<0.05); in particular TNF-α level increased in day 7 [(78.55±39.53) ng/L], and reached the peak at day 10 [(80.16±11.24) ng/L], and there was a significant difference(P<0.05); IL-6 levels increased at day 7 [(45.44±31.94) ng/L], and reached the peak at day 10 [(90.38±8.24) ng/L], and there was a significant difference(P<0.05). There was a no significant correlation between miR-125b and TNF-α in the hyperoxia groups (r=0.132, P>0.05), but there was significant correlation between miR-125b and IL-6 in hyperoxia groups(r=0.439, P<0.05).@*Conclusions@#The levels of miR-125b, TNF-α and IL-6 are involved in the pathological process of bronchopulmonary dysplasia induced by hyperoxia, and IL-6 may be the key factor for miR-125b.
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Objective To discuss the clinical effects of minimally invasive reduction and fixation with Zhang's reduction device for fractures of tibial intercondylar spine.Methods Five patients with tibial intercondylar spine fracture underwent treatment and reduction with Zhang's reduction device from December 2018 to February 2019 at Orthopedic Trauma Center,The Third Hospital of Hebei Medical University.They were 3 men and 2 women,aged from 25 to 56 years (average,43 years).The left side was affected in 2 cases and the right side in 3.By the Meyers classification,there were 2 cases of type Ⅱ and 3 ones of type Ⅲ.All the patients underwent the same surgical procedures and postoperative treatment.Their operation time,amount of bleeding,number of fluoroscopy required for insertion of guide pin,postoperative complications,fracture healing and knee joint range of motion at the last follow-up were recorded.Results The operation time for the 5 patients averaged 50.0 min,amount of bleeding 23.0 mL,and number of fluoroscopy required for insertion of guide pin 12.6 times.Their knee joint range of motion at the last follow-up ranged from 0° to 136.0°.All the incisions obtained primary union with no infection.Their hospitalization time ranged from 7 to 15 d (average,10.5 d).They obtained an average follow-up of 4.3 months (from 2 to 6months).All the fractures achieved union with no malunion,nonunion or refracture.Conclusions The minimally invasive reduction and fixation with Zhang's reduction device for fractures of tibial intercondylar spine can lead to satisfactory clinical effects.It is less invasive than open reduction and simpler than arthroscopic surgery so that it is more appropriate to be popularized in primary hospitals.However,this method has not been widely applied in clinic and more clinical trials are needed.
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Objective To analyze the short-term outcomes of rod-shaped glass bone graft for the treatment of tibial plateau fracture.Methods From January 2019 to February 2019,4 patients with tibial plateau fracture underwent minimally invasive reduction and new glass bone graft at Trauma Emergency Center,The Third Hospital of Hebei Medical University.They were 2 men and 2 women,aged from 31 to 67 years (average,42 years).The fractures happened at 3 left sides and one right side.According to Schanzker's classification,3 cases were type Ⅱ and one case was type Ⅲ.According to Zhang's classification for tibial plateau fractures,they were all type Ⅰ.The reduction was carried out under general anesthesia by a Zhang's traction device and a self-made rod.A rod-shaped glass bone graft of appropriate size was implanted along the bone tunnel.The plate was implanted through small incisions after fluoroscopy results were satisfactory.Intraoperative arthroscopic examination was used to assess fracture displacement before wound closure.The operation time,incision length,fluoroscopic frequency for insertion of guide needle,intraoperative blood loss,and short-term postoperative complications were recorded for each patient.Results The operation time for the patients averaged 37.5 min,the total length of all incisions 7.0 cm,the fluoroscopy required for insertion of guide needle 8.8 times,and the intraoperative blood loss 40.0 ml.All incisions were healed by the first intention.Postoperative intermuscular thrombosis occurred in 2cases.No postoperative infection or related complications happened.Conclusion Rod-shaped glass bone graft can lead to positive short-term outcomes for tibial plateau fractures,but a more reliable conclusion necessitates further clinical trials with a large sample size and long-term follow-up.
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Objective To study the clinical value of simultaneous amplification and testing for detection of Mycobacteria tuberculosis(SAT-TB)in sputum samples and bronchoalveolar lavage fluid(BALF)samples. Methods Totally 169 sputum samples and 151 BALF samples from suspected pulmonary tuberculosis patients were detected by both SAT and Bactec MGIT960.The sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)of the samples using SAT-TB were calculated. Results Taken the results of BD960 as the reference,the sensitivity,specificity,PPV and NPV using SAT-TB of sputum samples were 84.00% (42/50),93.06%(67/72),89.36%(42/47)and 89.33%(67/75)respectively;and those of BALF samples 89.19% (33/37),95.12%(39/41),94.29%(33/35)and 42.39%(39/92)respectively.Taken clinical diagnostic results as reference standard,the sensitivity,specificity,PPV and NPV using SAT-TB of the sputum samples were 57.73% (56/97),93.06%(67/72),91.80%(56/61),and 62.04%(67/108)respectively;and those of BALF samples 51.82%(57/110),94.29%(39/41),96.61%(57/59)and、42.39%(39/92)respectively.The sensitivity,specificity, PPV and NPV using BD960 of the sputum samples were 51.55%(50/97),95.83%(69/72),94.34%(50/53),and 59.48%(69/116)respectively;and those of BALF samples 33.64%(37/110),90.24%(37/41),90.24%(37/41) and 33.64%(37/110)respectively.Conclusion SAT-TB is a rapid and sensitive method for the detection of Myco-bacteria tuberculosis in sputum and BALF samples.It can improve the detection rate of mycobaterium tuberculosis.
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Brain-computer interface (BCI) technology enable humans to interact with external devices by decoding their brain signals. Despite it has made some significant breakthroughs in recent years, there are still many obstacles in its applications and extensions. The current used BCI control signals are generally derived from the brain areas involved in primary sensory- or motor-related processing. However, these signals only reflect a limited range of limb movement intention. Therefore, additional sources of brain signals for controlling BCI systems need to be explored. Brain signals derived from the cognitive brain areas are more intuitive and effective. These signals can be used for expand the brain signal sources as a new approach. This paper reviewed the research status of cognitive BCI based on the single brain area and multiple hybrid brain areas, and summarized its applications in the rehabilitation medicine. It's believed that cognitive BCI technologies would become a possible breakthrough for future BCI rehabilitation applications.
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Based on the dynamic performance of radial force sensor detection and TCM pulse waveform technology, the paper described a kind of testing equipment being developed which tests both radial force sensor performance and the dynamic performance of the instrument of pulse detection. The device covers requirements for static and dynamic performance test of the radial artery pulse wave force sensor and pulse diagnosis instrument, thus it makes a change to compute frequency response of the sensor by directly measurement.