RESUMEN
Talisadi Churna is a compound herbal formulation extensively used in disorders of upper respiratory tract and Gastro-intestinal tract. Formulation has greater demand due to its simple combination, therapeutic efficacy and methods of preparation and packaging due to which multiple companies prepare the formulation with due precision and safety evaluation. A current study was taken to evaluate in-house prepared sample of Talisadi Churna as per the AFI protocol and was compared to 3 different market samples. All the samples of Talisadi Churna were subjected to physico-chemical, preliminary phyto-chemical analysis and TLC. The study reveals that there is a significant difference is seen in the physico-chemical analysis and TLC, but there is no significant difference is seen in the preliminary phyto-chemical analysis.
RESUMEN
The present study aimed to evaluate the anti-asthmatic activity of the hydro-alcoholic extract of Citrullus colocynths and Cucumis trigonus (Cucurbitaceae) fruits on Ovalbumin induced Asthma in rats. Extracts were prepared with 70% v/v ethanol using cold maceration followed by Soxhlation. Hydro alcoholic extract (200 and 400 mg/kg) of both fruits were evaluated for anti asthmatic activity on ovalbumin induced Asthma in rats with the help of parameters like, absolute eosinophil count in BALF, total leukocyte count in the BALF, absolute eosinophil count in the Blood, IgE antibodies in serum and histopathological findings of lungs. Both plants were showed significant anti asthmatic activity (p < 0.001) with dose of 200 & 400 mg/kg when compared with disease group. Obtained results were almost similar to that of normal group. With the same dose, C. colocynths was shown better anti asthmatic activity than C. trigonus. Hence, further detailed studies are required to evaluate the efficacy of these plants on anti-asthmatic activity.
RESUMEN
The present study was attempted to evaluate diuretic potency of total alcoholic extracts and its polar and non polar fractions of Priyala fruits (Buchanania angustifolia, Buchanania lanzan Fam: Anacardiaceae) in rats. Healthy adult Wistar albino rats weighing about 150-200 g were used for the study. Acute toxicity study was performed to determine therapeutic dose of the extracts and fractions. Lipschitz method was employed for the assessment of diuretic activity, the control group received normal saline (25ml/kg P.O), and standard group received Frusemide (20mg/ kg, P.O). The remaining groups were treated with two doses (250 and 500mg/kg) of Buchanania angustifolia and Buchanania lanzan total alcoholic extracts, n-hexane insoluble and n-hexane soluble fractions. Total alcoholic extracts, n-hexane insoluble and n-hexane soluble fractions of the both fruits have shown significant diuresis when compared with control at 5 hrs. Out of two doses 500mg/kg has shown significant diuretic property resulting in the superior urine excretions of Na+ and K+ ions which can be compared to that of standard. With the same dose Buchanania angustifolia was found to be better diuretic than Buchanania lanzan. Priyala fruit extracts and n-hexane fractions produced significant diuretic effect at a dose of 500 mg/kg which appeared to be comparable with that of the standard drug Frusemide. However, further studies are encouraged to isolate the active phytochemical constituent for exploring exact mechanism of diuresis.