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Objective To explore the prevalence and analyze the related risk factors for post-stroke depression among middle-aged and elderly stroke patients of Mongolia and Han nationality in Inner Mongolia Autonomous Region.Methods A stratified multistage random cluster sampling method was used to investigate the prevalence of stroke in the population aged ≥45 years in different areas of Inner Mongolia Autonomous Region.A total of 11 088 people were investigated and 498 were stroke patients among them.A set of scale assessment and the general situation were used to investigate stroke patients and 443 patients completed the whole survey.Results The total prevalence of post-stroke depression (PSD) was 41.08％ in 443 stroke patients,among which the prevalence rate was 40.57％ for Mongolian population and 41.85％ for Han population,and no significant difference was found between Mongolian and Han nationality(x2=1.372,P=0.504).There were significant differences in the types of stroke between the Mongolian and Han nationality (x2 =7.347,P=0.025).The age (t=4.321,P=0.000),educational level (x2 =27.036,P=0.001) and economic burden (x2=27.877,P=0.000) were statistically significant between Mongolian and Han nationality.The differences of frequency of stroke (x2 =6.545,P=0.011),economic burden (x2 =16.148,P=0.001),cognitive dysfunction (x2 =9.065,P=0.003),daily living ability (x2 =34.466,P =0.000),alcohol consumption history(x2=4.516,P=0.034)were statistically significant.Logistic regression analysis showed that alcohol consumption history,economic burden,the frequency of stroke,and cognitive dysfunction were the influencing factors of PSD.Conclusion PSD is one of the important factors affecting the post-stroke psychological burden in Inner Mongolia Autonomous Region.There is no national difference in the prevalence of PSD among Mongolian and Han people,which provides a theoretical basis for the treatment and intervention of PSD.
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Prevalence of Alzheimer's disease,a neurodegenerative disease of the central nervous system,is increasing with the aging of population,causing serious social and family burdens.It is influenced by a variety of factors,including genetic and environmental ones.Epigenetics is an important bridge connecting genetic and environmental factors.DNA methylation,the most important modification in epigenetics,is related to many diseases like aging,cancer and dementia.In this paper,we reviewed the recent studies on the role ofDNA methylation in AD.
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To identify susceptible single nucleotide polymorphisms causing prevailing essential hypertension complicating stroke in the Mongolian population. This study was carried out at the Beijing Huada Genome Company, Beijing, and the Clinical Testing Center of Inner Mongolia Medical College, Hohhot, P. R. China from March to November 2005, and included 96 patients with hypertension [control group] with an average age of 53 +/- 11 years, and 68 patients with hypertensive stroke with an average age of 60 +/- 10 years. The gene polymorphisms were examined by the polymerase chain reaction-restriction fragment length polymorphism technique and the Sequenom system, and analyzed by multiple regression analysis. Logistic multiple regression analysis revealed significant differences between the groups for age and smoking. Genotypes and allele gene frequencies were not significantly different between the groups. The significant incidence risks were p=0.011, odds ration [OR]=3.182 for the ACE DD genotype, p=0.038, OR=6.179 for the CYP CT genotype, and p=0.042, OR=6.089 for the CYP TT genotype. All the other genotypes did not significantly correlate to hypertension and hypertensive stroke. The ACE DD, CYP CT and TT genotypes are candidates for hypertension complicating stroke in the Mongolian population. The risk of disease was lowest among the ACE II and CYP CC genotypes