RESUMEN
Ofloxacin, norfloxacin and pefloxacin, the recent quinolones were compared for their in-vitro antibacterial activity with the earlier ones as nalidixic acid, oxolinic acid and pipemidic acid against 110 recent hospital urinary isolates. The most active of the tested drugs were norfloxacin and ofloxacin [57.27% and 56.36%] followed by pefloxacin and oxolinic acid [both were 45.45%], while pipemidic acid and nalidixic acid were only 32.37% and 17.27%. The sensitivity to nitrofurantoin was 24.54% only. Pseudomonas isolates were more sensitive to the three new quinolones and piperacillin than to the earlier ones and nitrofurantoin. Norfloxacin and piperacillin gave high percentages of activity against those strains [78.90% and 68.42%]. 28 isolates showed multi-resistance to the earlier and recent quinolones. The MICs values of the resistant strains including Pseudomonas were higher [>128 mug/ml] with the earlier quinolones than the MICs of the recent ones [<32 mug/ml]
Asunto(s)
Quinolonas/farmacologíaRESUMEN
A multiresistant strain of Salmonella typhi was isolaled in Alexandria [Egypt] by blood culture from an Egyptian patient with persistent pyrexia under chloramphenicol therapy. It was found to be resistant to the standard anti-fciotics used for treatment of typhoid fever i.e chloramphenicol, ampicillin, tetracycline and trimethoprim-sulphame-thoxazole; the MICs for the first three agents being >l28, >128 and 128 micro g/ml respectively. The strain was susceptible to ofloxacin and cefotaxime. This non-lactose fermenting strain with a stable phenotypic resistance was recovered under chloramphenicol treatment. Blood culture and antibiotic susceptibility of the isolated strains should still be considered seriously in typhoid fever. Physicians and clinical microbiological laboratories should recognize the potential emergence of such multiresistant Salmonella typhi strains