Metaplastic Carcinoma with Extensive Chondroid Differentiation in the Breast (Chondroid Carcinoma)

Metaplastic breast carcinoma is very rare, and metaplastic carcinoma with chondroid differentiation is even rarer. Here, we report a case of metaplastic carcinoma with extensive chondroid differentiation mimicking chondrosarcoma that was challenging to diagnose. The tumor was characterized by an abundant chondromyxoid matrix. The definitive area of classic invasive ductal carcinoma was minimal. The peripheral portion of the tumor showed increased cellularity with pleomorphism and definitive invasive growth. Tumor cells in the chondrosarcomatous areas were diffusely immunoreactive for S-100 protein, patchy positive for cytokeratin, but negative for epithelial membrane antigen (EMA). Tumor cells in carcinomatous areas were diffusely positive for cytokeratin, S-100 protein, and patchy positive for EMA. In both areas, tumor cells were negative for smooth muscle actin (SMA) and CD34, while oncoprotein p53 was overexpressed. When pathologists encounter breast tumors with chondroid differentiation, careful sampling and immunohistochemistry for cytokeratin and SMA are most helpful to differentiate metaplastic carcinoma from malignant phyllodes tumor and malignant adenomyoepithelioma.

A Case of Schwannoma of the Trachea / 대한이비인후과학회지

Schwannoma is a distinct subset of peripheral nerve sheath tumor distinguished by unique histologic and immunohistochemical features. Tracheal schwannomas are among the rarest of tracheal tumors. The surgical approach to such tumors has been debated. We report a case of a primary tracheal schwannoma causing airway obstruction in a 52-year-old woman. Computerized tomography demonstrated an intraluminal growing mass in the trachea. Tracheofissure was performed to remove the mass. Histologic analysis revealed a benign neurogenic tumor of Schwann cell. We plan to follow up and examine the patient very carefully for the possibility of recurrence.