Hydroxychloroquine-induced Cutaneous Hyperpigmentation / 대한피부과학회지

The antimalarials have been commonly described for the treatment of several connective tissue diseases. Among adverse effects of antimalarials, skin hyperpigmentation has been easily overlooked for its slow onset, but it may be a marker at risk of ocular side effects. Moreover, most cases of hyperpigmentation have been reported from chloroquine, but rarely hydroxychloroquine (HCQ). We experienced two patients who showed skin pigmentation during administration of HCQ. The first case was a 53-year-old woman presented with dark brown macules on the neck and ashy-colored patches on the buttock. The second was a 75-year-old woman presented with bluish-gray patches on both shins. Before hyperpigmentation developed, each patient had been treated with HCQ 400 mg per day for two years and five months, respectively. Two years ago after skin hyperpigmentation the first patients was found to have retinal pigmentation under the fundoscopy, so that HCQ was discontinued.

Linear Atrophoderma of Moulin with Bilateral Involvement / 대한피부과학회지

Linear atrophoderma of Moulin is a rare acquired atrophic skin condition following the lines of Blaschko. It is characterized by asymptomatic, band-like, hypopigmented atrophoderma, without obvious induration or sclerosis. Usually, the lesions begin in childhood or adolescence and are localized on the trunk or extremities with a unilateral distribution. Extensive lesions with bilateral involvement are extremely rare, and only three cases affecting patients bilaterally have been previously described. We herein present the case of a 17-year-old boy with multiple hyperpigmented atrophic patches, arranged in a linear pattern on both sides of the trunk, right buttock and leg, and left arm.