RESUMEN
To investigate the sensitivity pattern of Staphylococcus aureus isolates obtained from clinical specimens including urine, wound, high vaginal swab and semen to commonly used antibiotics. The susceptibility patterns of these isolates were determined using the disc diffusion and agar well diffusion methods. Out of 174 samples, 51 [29.2%] yielded S. aureus with the highest isolation from semen [66.7%] and the least from urine [15.6%]. Following the disc diffusion, the highest sensitivity was recorded for Ofloxacin [65%] while the least was for Co-trimoxazole [6%]. Amoxicillin, Ampicillin, Tetracycline and Cloxacillin recorded 37%, 19%, 8% and 11% respectively. Also, following the agar well diffusion method, the highest sensitivity was recorded for Ofloxacin [65%] and the least for Co-trimoxazole [8%]. The other drugs recorded the following readings; Amoxycillin [37%], Ampicillin [21%], Tetracycline [23%] and Cloxacillin [13%]. The study recommends the use of Ofloxacin in the treatment of S. aureus infections in the study area. It also underscores the need for sensitivity testing before the administration of antibiotics for the treatment of Staphylococcal infections