Effect of C14 ethoxy profenofos insecticides on liver and kidney functions of lactating goats

Egyptian healthy baladi goats at the middle of lactating period were classified into two groups, the first group G[1] was kept as non-treated control, while the second group, 6 goats were orally administered the calculated C[14] -Ethoxy profenofos at a dose level 17.9 mg/kg /Body weight/day for 7 successive days. After stoppings of toxicant administration, three goats G2 were sacrificed and the other three animals' G3 were given normal feed for 14 days. Blood samples were taken for determine liver and kidney functions. The distribution of C[14] activity in liver, kidney, fat and muscle tissues showed that the tested organs in G2 contain more C[14] -activity than those in G3. The C[14] -residue levels were found to be high in liver and kidney than in fat and muscle tissues. Significant changes were noticed in GOT, GPT, alkaline Phosphatase, cholesterol, albumin, urea and creatinine during the toxicant administration and returned towards normal values after 14 days recovery

Fate of ethyl-1-14c-labeled chlorpyrifos in cotton leaf worm

The absorption, metabolism and degradation of 14 ethyl-1-[14] C-labelled chlorpyrifos in the adult larvae of cotton leaf worm has been investigated in vivo. The synthesis of 14 ethyl-1-[14]- C-chlorpyrifos and some of its degradation products are described. Following topical application of the radioactive insecticide, about 66 percent of the initially applied dose was metabolized in 24 hr. The identified metabolites were 0-ethyl-0-3,5,6-trichloro-2-pyridyl phosphorothioate, 0,0-diethyl-0-3,5,6-trichloro-2-pyridyl phosphate and 0-ethyl-0-3,5,6-trichloro-2-pyridyl phosphate. Three of the isolated degradation products are still unknown

Short term toxicity studies on Dursban and Gardona in mice

The toxicity and the in vivo cholinesterase activity of the two insecticides dursban and gradona in mice have been investigated following different routes of application. Dursban inhibited both erythrocyte and plasma cholinesterase but gardona had no effect on the activity of erythrocyte enzyme. These studies were carried out by pure insecticides synthesized in our laboratory