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Indian J Lepr ; 1995 Oct-Dec; 67(4): 375-82
Artículo en Inglés | IMSEAR | ID: sea-55488

RESUMEN

Among the four newly synthesized benzoxazinorifamycin derivatives, KRM-1648 and KRM-2312 completely inhibited the multiplication of rifampicin-sensitive as well as rifampicin-resistant strains of M. leprae in the foot-pads of mice. Both were found to be more potent than rifampicin and were bactericidal. In combination with ofloxacin, another potent bactericidal drug against M. leprae, both KRM-1648 and KRM-2312 exhibited synergism. Thus, combination of one of these benzoxazinorifamycin derivatives and ofloxacin in multidrug regimens is worth evaluating in clinical trials.


Asunto(s)
Animales , Leprostáticos/farmacología , Ratones , Ratones Endogámicos BALB C , Mycobacterium leprae/efectos de los fármacos , Rifamicinas/farmacología
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