RESUMEN
Tetanus is a common disease of tropical and subtropical countries with high mortality rate, its tetanospasmin inhibits cholinesterase enzyme leading to accumulation of acetyl choline at motor nerve endings. Therefore choline esterase restoring drug chemically designated as obidoxim chloride was added to the classical lines of treatment of tetanus. No mortalities were recorded in cases suffering from moderate type of tetanus after the use of obidoxim chloride while patients who received the classical treatment without the use of choline esterase reactivator had a mortality rate of 37.5%. The mortality rate was reduced from 62.5% to 22.72% in serve cases of tetanus. The period needed for improvement of the clinical manifestations [trismus, muscle rigidity and spasms] was shortened in all cases after adding choline esterase reactivator to the classical line of therapy