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Scientific Medical Journal. 2003; 15 (1): 21-35
en Inglés | IMEMR | ID: emr-64890

RESUMEN

This multicenter phase II study was designed to assess the efficacy and tolerability of the combination of irinotecan with bolus 5-FU and calcium leucovorin [LV] as a front line therapy for advanced colorectal cancer [CRC]. Patients with histologically proven advanced CRC and at least one measurable lesion, with age range 18-75 years, with a performance status of <2, normal baseline biochemical values and no prior chemotherapy [apart from adjuvant] were selected. The treatment regimen was formed of weekly CPT-11 [125 mg/m2] i.v. infusion, 5-FU [500 mg/m2] bolus i.v. and LV [20 mg/m2] i.v. for four weeks [two weeks, followed by two weeks rest, this constitute one cycle]. Treatment continued till either complete remission or disease progression or failure


Asunto(s)
Humanos , Masculino , Femenino , Fluorouracilo , Leucovorina/farmacología , Quimioterapia Combinada , Pruebas de Función Hepática , Pruebas de Función Renal , Resultado del Tratamiento , Estudios de Seguimiento
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