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Indian J Med Sci ; 2001 Oct; 55(10): 549-52
Artículo en Inglés | IMSEAR | ID: sea-68808

RESUMEN

PG synthesis plays major role in inflammation. The enzymes responsible for PG synthesis are cox-1 and cox-2. Cox-1 regulates physiological functions in gut and kidney while cox-2 induces inflammation. Selective cox-2 inhibitors have little effect on cox-1 and thus showed better GI tolerability. The efficacy of new drugs is not greater than that of NSAID's by oral route of administration. In the present study new selective cox-2 inhibitors also showed less efficacy than NSAID'S by topical route of administration. However if current studies confirm the reduced GI toxicity this can be the only advantage of these drugs because these drugs showed less efficacy than NSAID'S by oral and topical routes of administration.


Asunto(s)
Administración Tópica , Animales , Antiinflamatorios no Esteroideos/administración & dosificación , Química Farmacéutica , Ciclooxigenasa 2 , Inhibidores de la Ciclooxigenasa 2 , Inhibidores de la Ciclooxigenasa/administración & dosificación , Edema/tratamiento farmacológico , Geles , Isoenzimas/antagonistas & inhibidores , Prostaglandina-Endoperóxido Sintasas , Ratas , Vehículos Farmacéuticos
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