RESUMEN
Actinomycosis is a chronic and less common infectious process that established by Actinomyces israilii. Involvement of faciocervical region is more common than thermic and visceral types and typicality involves the angle of mandible and with less occurrence rate the upper jaw may also be involved. Periapical lesions of maxilla that involved in this process by Actinomyces israilii are rare and common site of them is the periapical area of central incisors of maxilla. A subject is a 31-year-old woman who after multiple effort of endodontic and surgical procedures eventually with meticulous surgical debridement and pathologic examination with diagnosis of periapical actinomycosis was treated with penicillin for I0 weeks and after that showed no sign and symptom in involved area