RESUMEN
To analyze the chromosomal abnormalities in couples with history of recurrent abortions. Retrospective study. Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan. Three hundred couples with history of recurrent abortions. Structural chromosomal abnormalities in carrier couples. G-banded chromosomes were analyzed from both partners of 300 couples who had had two or more spontaneous abortions. Sixteen [5.3%] couples showed a chromosomal aberration in one of the partners. Seven translocations, 5 inversions, 2 deletions and 2 sex chromosomal abnormalities were identified. There was an increase in structural aberations, which was not significantly different from that reported worldwide. Chromosomal analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage
Asunto(s)
Humanos , Masculino , Femenino , Aborto Habitual/etiología , Aberraciones Cromosómicas , Embarazo , Hospitales Universitarios , Estudios RetrospectivosRESUMEN
To evaluote fetal status for B. Thalassemia. During 1994-99, one hundred and twenty women with B thalassemia minor underwent Chorion Villus Biopsy in early pregnancy to determine the fetal status. Aga Khan University Hospital, Karachi. Seventeen pregnancies were found to have B. Thalassemia major, 86 embryos had B. Thalassemia minor and seventeen were Thalassemia free. All the couples were given genetic counselling to make decision regarding management of the current pregnancy affected by B. Thalassemia. During initial phase of this study the undesirable side effects of the trans vaginal procedure in 2 cases were excessive vaginal bleeding and abortion. The sample was obtained after two attempts in these cases
Asunto(s)
Humanos , Femenino , Diagnóstico Prenatal , Embarazo , Muestra de la Vellosidad Coriónica , BiopsiaRESUMEN
Induction of labor near term in selected cases to procure a vaginal delivery of a selected time. The Aga Khan University Hospital, Karachi 1995 - 1996. Labor induced after ripening of the cervix with Folly's catheter, Prostine vaginal Pessary. Labor pains initiated with Prostaglandins, ARM syntocinon infusion or both. Vaginal/abdominal delivery with due safety to mother and child. Vaginal deliveries obtained in 89.2% cases, 10.8% cesarean section rate, no maternal or fetal mortality