RESUMEN
Introduction: Tumors like Odontogenic Keratocyst (OKC), Dentigerous Cyst (DC)and Pyogenic Granuloma are frequently oc- curring in the oral cavity with each of them having relation to angiogenesis. Higher angiogenesis may be associated with increased tissue metabolism, more aggressive biologic behaviour, and increased recurrence and growth rate. Tumor growth is dependent not only on a rise in the number of blood vessels, but also on factors such as protein molecules produced in en- dothelial cells. Microvessel density (MVD), Microvessel area (MVA), Microvessel perimeter (MVP) can predict the growth of the tumour, metastasis and patient’s survival and this value is related to the aggressiveness of the tumour. Aims: The aim of the present study was to determine the angiogenic potential of OKC and DCcompared with normal mucosa using CD 105 marker immunohistochemically. Materials and methods: Immunohistochemical staining was done on 70 paraffin embedded tissue samples. Histopathologi- cally diagnosed cases of OKC, DC and Pyogenic granuloma and healthy gingival tissue samples were retrieved for the study purpose. Results: There was no statistically significant difference in the mean MVD, MVA, MVP values of OKC, DC and pyogenic granu- loma groups. Conclusion: The angiogenic potential was determined in 3 different cases of OKC, Dentigerous Cyst and Pyogenic granuloma in terms of MVD, MVA and MVP and compared to normal mucosa using CD105 marker immunohistochemically.Though the mean values of MVA, MVD, MVP were statistically not significant but was estimated to be higher than the normal mucosa
RESUMEN
Introduction: Epidermoid cysts are cystic malformations filled with keratin and lipid rich debris. They generally present as benign, soft, and freely movable, slowly enlarging, and non-tender masses, commonly located on the face, neck and trunk of the body. They are more commonly seen in ovaries and gonads, and less often in head and neck region. Approximately 7% of epidermoid cysts are present in the head and neck region and about 1.6% are found in the oral cavity. They can be either congenital or acquired in origin. Congenital epidermoid cyst occurs at third and fourth intra-uterine life due to entrapment of ectodermal elements entrapped during midline fusion of first and second branchial arches. However, acquired epidermal cysts occur due to implantation of epidermal elements following cystic transformation. Case presentation: In this article, we discuss a case of epidermoid cysts presenting in multiple areas of the face which clinically appeared to as acquired nevi (mole). Management/Prognosis: Based on clinical appearance and provisional diagnosis, treatment of mole was made. The lesions were excised by electrocautery and sent for histopathological evaluation. Conclusion: There was a drastic difference between the clinical appearance and histopathological picture seen. A thorough knowledge about etiology, clinical history and histopathology is needed to reach an accurate diagnosis
RESUMEN
Ground sections of teeth or bone are considered best solutions for the study of any hard tissues in the study of histopathology. Various studies have been performed like progression of dental caries, enamel studies, dentin studies, cementum annulation studies, bone morphologies, age determinaton studies, etc. It is important study part in any forensic studies where mass disasters occurring as natural phenomenon of cyclonic events, earth quakes, floods and volcanic explosions and airplane accidents, industrial accidents and terror related acts. Forensic dentistry has played a vital role and many medico-legal cases are solved by studying the teeth. Ground sections study is important in any part of research. For a dentist this phenomenon is less understood, and this article brings in limelight various methods and study pattern of ground sections of teeth. With this knowledge an understanding and performing ground sections of teeth becomes a well start for dental graduates. Various other modalities in histopathology are decalcification studies, histopathological staining procedures, special stains procedures, immunohistochemistry. All the histopathological modalities have their own importance and are used appropriately in the study of oral pathology.