Synthesis and antimicrobial studies of some novel isoxazoline derivatives.

In the present investigation, a series of novel isoxazoline derivatives 4a-i were synthesized by cyclization of 1-(2’-hydroxy phenyl)-5-(6’’-methoxynaphthalen)-2-propene-1-one (i.e. Chalcones) 3a-i with hydroxylamine hydrochloride in dimethyl formamide and sodium acetate to obtained 3-(2’-hydroxy phenyl)-5-(6’’-methoxynaphthalen)-2-isoxazolines 4a-i. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, mass and elemental analysis. All the compounds were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria. Several derivatives of isoxazoline produced good to moderate activities against number of bacteria and fungus.