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1.
Indian J Med Sci ; 2001 Jun; 55(6): 319-25
Artículo en Inglés | IMSEAR | ID: sea-67579

RESUMEN

Serum proteins and plasma fibrinogen were estimated in 103 patients in various groups of leprosy and 52 patients of reactional leprosy. Total proteins, serum globulin and fibrinogen showed significant rise while serum albumin showed fall over the immunological spectrum from TT to LL. Type II reactional leprosy similarly revealed significant rise in globulin and fibrinogen. The comparison of these parameters between most of the comparable groups of leprosy was statistically significant. ENL patients after complete subsidence of reaction and after steroid treatment showed significant decrease in these protein fractions, thus conferring some prognostic implication on these tests.


Asunto(s)
Proteínas Sanguíneas/metabolismo , Fibrinógeno/metabolismo , Humanos , Lepra/sangre
2.
Indian J Lepr ; 2000 Oct-Dec; 72(4): 451-5
Artículo en Inglés | IMSEAR | ID: sea-55432

RESUMEN

The effect of local treatment of nostrils with fusidic acid cream was investigated in 30 previously untreated lepromatous leprosy patients. The cream was applied in the nostrils after flushing the nostrils with normal saline, twice a day for a period of four weeks. It was found that 20 mg/gm of sodium fusidate was effective in reducing the morphological index of the nose-blow smear to zero in two weeks in majority of the patients. No untoward side effect was seen in any of the patients. Such nasal treatment along with multidrug therapy may help in reducing the patient's level of infectiousness to their contacts, since the nose is recognized to be an important portal of exit of M. leprae.


Asunto(s)
Administración Intranasal , Adulto , Antibacterianos/administración & dosificación , Quimioterapia Combinada , Femenino , Ácido Fusídico/administración & dosificación , Humanos , Leprostáticos/administración & dosificación , Lepra Lepromatosa/tratamiento farmacológico , Masculino , Mycobacterium leprae/efectos de los fármacos , Mucosa Nasal/microbiología
3.
Indian J Lepr ; 1995 Oct-Dec; 67(4): 383-8
Artículo en Inglés | IMSEAR | ID: sea-55129

RESUMEN

A comparative study of the effect of wax therapy and foot soaks on dry plantar skin was conducted in patients with leprosy. Thirty patients with varying grades of fissures and callosities were given wax therapy for feet, and 20 similar patients were given foot soaks. Patients given wax therapy felt subjectively much better than those who had soaking. Healing of cracks and fissures and softening of callosities was observed more frequently in patients with wax therapy. These differences are statistically significant. As an institutional method wax therapy has definite advantages for treating patients with fissures and callosities, whereas soaking of the feet is easy and readily available in patients' homes to restore the dry skin to normal.


Asunto(s)
Enfermedades del Pie/terapia , Humanos , Lepra/complicaciones , Ceras/uso terapéutico
4.
Indian J Lepr ; 1994 Jan-Mar; 66(1): 51-7
Artículo en Inglés | IMSEAR | ID: sea-54887

RESUMEN

Effect of oral zinc as an immunomodulator was studied clinically in patients with recurrent ENL over a period of one year. In this study, 40 leprosy patients with chronic ENL, requiring more than 30-40 mg of prednisolone/day for the control of their reactions, were given oral zinc sulphate for a period of four months, and, marked improvement in the frequency, duration and severity of reactions was observed after zinc therapy. Also evident was marked reduction in the steroid requirement after oral zinc therapy. It appears that zinc may be a good substitute for the present day anti-reaction treatment which is not free from disadvantages. Further investigations to know the precise action of zinc on immune-system may help to understand the role of zinc therapy and its optimum duration.


Asunto(s)
Administración Oral , Adolescente , Adulto , Eritema Nudoso/tratamiento farmacológico , Femenino , Humanos , Lepra Lepromatosa/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Recurrencia , Zinc/administración & dosificación
5.
Indian J Lepr ; 1992 Oct-Dec; 64(4): 461-7
Artículo en Inglés | IMSEAR | ID: sea-55246

RESUMEN

A preliminary study of anti-phenolic glycolipid-I (PGL-I) IgM antibody detection using M. leprae gelatin particle agglutination (MLPA) test kit is described. Antibodies were demonstrated in 70% of our leprosy patients taking antileprosy treatment. The percentage of positivity of multibacillary cases was 86.0, whereas that of paucibacillary cases was 30.0. Good correlation was found between bacteriological index and the presence of antibodies. Antibodies were detected in 28% of our patients released from treatment. Fourteen out of 27 household contacts were found to have antibodies but none of the normal controls were seropositive. These preliminary data demonstrate that MLPA test is not applicable as sero-diagnostic test or as a test of cure, but may be useful for epidemiological studies and as a research tool.


Asunto(s)
Pruebas de Aglutinación , Anticuerpos Antibacterianos/análisis , Antígenos Bacterianos/inmunología , Gelatina , Glucolípidos/inmunología , Humanos , Lepra/diagnóstico , Mycobacterium leprae/inmunología
6.
Indian J Lepr ; 1992 Oct-Dec; 64(4): 501-4
Artículo en Inglés | IMSEAR | ID: sea-55071

RESUMEN

One of the technical problems relating to the multidrug therapy of leprosy is the slow decrease in the bacteriological index (BI) in multibacillary patients. In this study we have compared a regimen containing rifampicin given daily for 9 months with the standard WHO multidrug regimen for multibacillary leprosy. We have found, at the end of two years, a significantly greater fall of BI in patients who had received the regimen containing daily rifampicin as compared to those who had received pulsed doses of rifampicin. The doses of dapsone and clofazimine were similar in these two groups. It appears that daily administration of rifampicin may be useful in treating multibacillary patients in whom reduction in the BI is slower than expected. However, in view of its high cost and the very much increased incidence of type-2 lepra reactions and hepatitis, daily rifampicin therapy cannot be recommended for a control programme.


Asunto(s)
Adolescente , Adulto , Clofazimina/administración & dosificación , Dapsona/administración & dosificación , Esquema de Medicación , Quimioterapia Combinada , Femenino , Humanos , Lepra/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Rifampin/administración & dosificación
7.
Indian J Lepr ; 1990 Jul-Sep; 62(3): 316-20
Artículo en Inglés | IMSEAR | ID: sea-54668

RESUMEN

A clinical experience of using thalidomide in type-2 lepra reaction (ENL) in 90 male patients--57 with lepromatous leprosy (LL) and 33 with borderline lepromatous leprosy (BL)--is described. All the patients responded well although some took a longer time to improve. No major side effects were observed except for giddiness in 10 and gastrointestinal upsets in 7 patients. Thalidomide thus appears to be a very effective drug in the treatment of severe type-2 lepra reaction and apart from its historically well-documented embryopathic effects, does not seem to have any other serious side effects in the patients under study.


Asunto(s)
Adolescente , Adulto , Antiinflamatorios no Esteroideos/uso terapéutico , Quimioterapia Combinada , Humanos , Lepra Lepromatosa/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Talidomida/efectos adversos
8.
Indian J Lepr ; 1990 Jul-Sep; 62(3): 368-70
Artículo en Inglés | IMSEAR | ID: sea-55510
9.
Indian J Lepr ; 1990 Apr-Jun; 62(2): 208-14
Artículo en Inglés | IMSEAR | ID: sea-55374

RESUMEN

Fibrinolytic activity in eighty-one patients with different types of leprosy and thirty-two normal healthy controls was studied by Euglobulin Lysis Time Method, Fibrinolytic activity was markedly decreased in patients with lepromatous leprosy and those with ENL reaction. Decline in fibrinolytic activity during ENL was independent of frequency of attacks. Fibrinolytic activity was partly restored after subsidence of ENL reaction, though it failed to attain normal levels. Cutaneous vasculitis seems to be most probable cause of fall in fibrinolytic activity in lepromatous leprosy and ENL reaction.


Asunto(s)
Eritema Nudoso/sangre , Fibrinólisis , Humanos , Lepra Lepromatosa/sangre
10.
Indian J Lepr ; 1989 Jan; 61(1): 92-5
Artículo en Inglés | IMSEAR | ID: sea-54643

RESUMEN

Three hundred and sixty six in-patients in a leprosy hospital were examined for other dermatological conditions. Eighty eight of them displayed ichthyosiform changes. A peculiar condition of a verrucous hyperkeratotic growth on the anterior aspect of ankle, not described previously, was observed in four patients. It was noted that 11 out of 12 patients with scabies did not have the classical lesions in web spaces of the hands.


Asunto(s)
Clofazimina/efectos adversos , Erupciones por Medicamentos/complicaciones , Femenino , Humanos , Pacientes Internos , Queratosis/complicaciones , Lepra/complicaciones , Masculino , Trastornos de la Pigmentación/inducido químicamente , Escabiosis/complicaciones , Enfermedades de la Piel/complicaciones
11.
Indian J Lepr ; 1988 Jan; 60(1): 84-6
Artículo en Inglés | IMSEAR | ID: sea-54950

RESUMEN

Two cases of 'flu' syndrome on once monthly rifampicin are reported. The symptoms were reproduced in one patient with the next supervised dose. In the second patient they did not recur probably because she was receiving systemic steroids for left ulnar neuritis.


Asunto(s)
Adulto , Mareo/inducido químicamente , Esquema de Medicación , Femenino , Fiebre/inducido químicamente , Humanos , Lepra Dimorfa/tratamiento farmacológico , Rifampin/administración & dosificación , Tiritona , Síndrome
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