RESUMEN
Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm that develops in the abdominal cavity in young people. Microscopically, nests of small undifferentiated cells within a desmoplastic stroma are observed and immunohistochemical studies show polyphenotypic differentiation with expression of epithelial, neural and muscle markers. A specific chromosomal translocation, t (11;22)(p13;q12) has been documented in DSRCT and is increasingly used to confirm the diagnosis. We had experienced a 59-year-old female with right upper quardrant pain for 1 month. On abdominal computerized tomography, multiple demarcated intrahepatic mass lesions were found, but other organs metastasis or abnormal lymph node enlargement and fluid collection were not found. Fine needle aspiration biopsy of hepatic mass was performed and DSRCT was diagnosed by H and E and immunohistochemical staining. She was treated with cyclophosphamide, etoposide, doxorubicin and cisplatin. After three cycles of chemotherapy, computerized tomography demonstrated distinct shrinkage of tumor. At present, she continues in the state of partial remission for 15months after chemotherapy was started.
Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Cavidad Abdominal , Biopsia , Biopsia con Aguja Fina , Cisplatino , Ciclofosfamida , Tumor Desmoplásico de Células Pequeñas Redondas , Diagnóstico , Doxorrubicina , Quimioterapia , Etopósido , Ganglios Linfáticos , Metástasis de la Neoplasia , Translocación GenéticaRESUMEN
We report the case of a 47-year-old female who developed idiopathic eosinophilia-myalgia syndrome following complete remission of non-Hodgkin's lymphoma. She had been diagnosed extranodal marginal zone B cell lymphoma of nasal cavity and treated with CHOP chemotherapy and radiotherapy. She complained fever, myalgia and the complete blood count showed markedly elevated eosinophil count. Non-Hodgkin's lymphoma was confirmed in complete remission state by PNS CT, nasal septum biopsy and bone marrow biopsy. The patient showed eosinophilia in peripheral blood, myositis in electromyography and muscle biopsy consistent with eosinophilia-myalgia syndrome. The symptoms were improved and the eosinophilia count was decreased after prednisolone medication. We report a case of idiopathic eosinophilia-myalgia syndrome with a review of the literature.