The distribution of HPV subtype and multiple HPV infection in cervical cancer and precancerous lesion / 부인종양

OBJECTIVE: To evaluate the distribution of HPV subtype and multiple HPV infection in cervical cancer and precancerous lesion with HPV DNA chip in Korean women. METHODS: We recruited a total of 145 women diagnosed with cervical cancer or cervical intraepithelial neoplasia (CIN), and 404 normal women as control between Dec. 2004 and Sept. 2005. We investigated the distribution of HPV subtype and the multiple infection according to cervical lesion. RESULTS: Of the 145 women, 132 (91.0%) showed HPV infection and 111 (76.6%) showed high risk HPV infection by HPV DNA chip. HPV 16 (48/145, 33.1%) was the most common type, and followed by HPV 58, 18, and 33 in CIN or cervical cancer than control (p<0.05). Multiple infections were more common in CIN or cervical cancer than control. There was no correlation between the incidence of multiple HPV infection and cervical lesion in young women (<35 years). In women over 36 years of age, however, multiple infections were the most frequently detected in CIN. CONCLUSION: The types of HPV 16, 58, 18, 33 were common in cervical precancerous or cancer lesion by order of frequency. Multiple infections were common in women under 35 years of age, and in women with CIN over 36 years of age.

Delayed delivery of the second twin / 대한산부인과학회지

We describe a case of diamniotic dichorionic pregnancy at 23 weeks and 6 days of gestation with threatened preterm labor with rupture of membrane of twin one. After 10 days we delivered the first twin. We decided to retain the other one to allow improvement in the outcome for the second twin. The patient was treated with tocolytics, antibiotics, cervical cerclage, steroid and continously monitored. After 58 daysthere was increasing uterine contractility and we delivered the second twin.