Two Cases of Acute Generalized Exanthematous Pustulosis / 대한피부과학회지

Acute generalized exanthematous pustulosis(AGEP) is characterized by the abrupt onset of widespread pustules on an erythematous base and rapid spontaneous healing. Most cases appear to be related to drug reactions, mainly antibiotics, viral infections, and hypersensitivity to mercury. We report two cases of acute generalized exanthematous pustulosis which presented with widespread tiny pustules on the whole body. Histopathologic examinations of both cases showed subcorneal neutrophilic pustules with perivascular polymorphous cellular infiltration. We suspected that the possible cause of two cases was inhalant mercury and carbamazepine.

A Case of Desmoplastic Nevus / 대한피부과학회지

Desmoplastic nevus, a benign melanocytic neoplasm characterized by predominantly spindle-shaped nevus cells within a fibrotic stroma without junctional activity, nesting, or pigmentation, can be confused with fibrous lesions and other melanocytic proliferations, including desmoplastic melanoma. We report a rare case of desmoplastic nevus occurring in the left helix of the ear of a 25-year-old woman, which has typical histopathologic features of desmoplastic nevus.

A Case of Bilateral Chondrodermatitis Nodularis Chronica Helicis on the Concha of Auricles / 대한피부과학회지

Chondrodermatitis nodularis chronica helicis is a painful erythematous, often crusted, papule most commonly found on the helix of the ear of men over the age of 40 years. It is seen less commonly in women, in whom it is usually located on the antihelix. The lesions usually occur unilaterally, although bilateral involvement has been reported. We report an unusual case of chondrodermatitis nodularis chronica helicis in an 86-year-old woman, which presented with bilateral involvement of the concha of auricles.

Vitamin C-iontophoresis in Melasma / 대한피부과학회지

BACKGROUND: An inhibitory effect of ascorbic acid(AsA) on melanogenesis has been described. Iontophoresis is emerging technologies capable of enhancing drug penetration through stratum corneum, the principal barrier to percutaneous absorption. OBJECTIVE: Our purpose of this study was to evaluate the efficacy of vitamin C-iontophoresis in patients of melasma. METHODS: The treatment was performed twice weekly in 15 volunteer patients for a period of 6 weeks by application of vitamin C under a constant direct current of 0.4-0.8A for 15minutes. Clinical evaluations using the Melasma Area and Severity Index(MASI) and bioengineering measurement using Chromameter CR 300(R) were taken before and after treatment. RESULTS: Decreased MASI and light reflectance were noted at the end of 6 weeks, significant clinical improvement in the melasma was seen compared to before treatment. CONCLUSION: Vitamin C-iontophoresis is an effective, noninvasive treatment of melasma without significant side-effects.

A Case of Antiphospholipid Syndrome in A Patient with Leg Ulcer and Previous History of Deep Vein Thrombosis / 대한피부과학회지

The antiphospholipid syndrome is a multiple-system disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia, or recurrent spontaneous abortion. Various cutaneous manifestations have been associated with this disease and may be the first sign of the underlying problem. We report a case of antiphospholipid syndrome with cutaneous ulcer on the left calf of a 21-year-old woman, who has been treated with deep vein thrombosis.

A Case of Angiolymphoid Hyperplasia with Eosinophilia / 대한피부과학회지

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign tumor, characterized by marked proliferation of endothelial cells. ALHE shows histopathologic feature of extensive infiltrate of lymphocytes, histiocytes and numerous eosinophils, and occurs on the head and neck of young adults. We report a case of ALHE in a 49-year-old woman. Histopathologic examination revealed lymphoid follicles with germinal centers and proliferation of irregular capillaries with plump endothelial cells, sometimes atypical in appearance, protruding into the lumen of the blood vessels.

A Case of Juvenile Xanthogranuloma Localized in Papillary Dermis / 대한피부과학회지

Juvenile xanthogranuloma is characterized histologically by a dense, sheetlike, well-demarcated, histiocytic infiltration within the papillary and reticular dermis, with occasional extension into subcutaneous tissue, fascia, and peripheral muscle. We report a case of juvenile xanthogranuloma developed in a 5-month-old male infant which showed typical histopathologic features of juvenile xanthogranuloma, involving the papillary dermis only without deep dermal or subcutaneous change.