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Artículo en Inglés | IMSEAR | ID: sea-64155

RESUMEN

BACKGROUND: Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor. METHODS: Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects. RESULTS: Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation. CONCLUSION: Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.


Asunto(s)
Resistencia a la Proteína C Activada/genética , Adolescente , Adulto , Anciano , Niño , Preescolar , Factor V/genética , Femenino , Predisposición Genética a la Enfermedad , Heterocigoto , Homocigoto , Humanos , India/epidemiología , Lactante , Masculino , Venas Mesentéricas/patología , Persona de Mediana Edad , Polimorfismo de Longitud del Fragmento de Restricción , Vena Porta/patología , Vena Esplénica/patología , Trombosis de la Vena/genética
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