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Background: Quality of life (QoL) is a standard indicating a person抯 life in better condition as compared to a diseased person or patient. Diabetes itself is not a dangerous disease if managed properly, but it becomes life-threatening after a certain time period because of the patient抯 poor interest in disease management and treatment adherence. Diabetes mellitus is an endocrine system disorder that invokes lack of insulin secretion in the bloodstream. The study was conducted to assess the QoL of type-2 diabetes mellitus patients with QoL instrument.Methods: Questionnaire based cross-sectional, prospective study was conducted at Teerthanker Mahaveer Hospital, Moradabad, for a duration of 6 months from January - June 2019, on 196 patients of type-2 diabetes mellitus.Results: On an average 56.5% people have accepted that due to the diabetic condition their working proficiency is decreased. 80.3% of patients have accepted that they were facing problems due to diabetic symptoms. Similarly, 84% of patients have accepted that the ongoing treatment was quite expensive than their expectations. Finally, the last section of the patient抯 emotional/mental satisfaction showed that 49.7% of patients were very satisfied with their family support while 13.7% of patients were not satisfied.Conclusions: QOL instrument for Indian diabetes patient抯 instrument helped to evaluate the patient抯 physical strength, psychological strength of the patient during disease condition, the response provided from the family members and relatives, the economical status of the patient and its effects on their living.
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In Ayurveda, Shalyatantra is one of the eminent branches based on six major methods of management among which Agnikarma is boon for local Vata and Kaphaja Vyadhi. Its effect can be assessed as Sthanik Karma (local action), Saarvadaihik Karma (Action throughout the body) and Vishista Karma (Special actions). Based on amount of Agni needed, the condition and site of disease, Dahanupakarana are used to produce therapeutic burns during Agnikarma Chikitsa. It can be classified according to Dravya used, site, disease, Akritiand Dhatu to be cauterized. Based on the Dagdha (Burn), it is again of four type viz. scorched burn, blistered burn, superficial burn and deep burn. Its indication is in all seasons except in summer and autumn. Indications and contraindications are well expounded in classics with detail information on Purva Karma, Pradhana Karma and Paschat Karma during Agnikarma as it is superior to every other procedure used in Ayurveda Surgery. In modern medicine, there is no use of therapeutical burn i.e., Samyak Dagdha Chikitsa but its use is in other form eg., Cauterization is used for coagulation and tissue destruction. Agnikarma is considered as the best therapy to pacify Kaphanubandha Vata Dosha because Agni possesses Ushna, Tikshna, Sukshma, Aashukari Gunas, which have anti Vataja and anti Kaphaja properties. It is done by red hot Shalaka. It gives quick relief to the patient and hence is termed as best therapy.
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Background: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy and in many centers, it is still a part of the diagnostic armamentarium. In this study, the histopathological spectrum of the nerve biopsies received is being revisited to analyze the various clinical and pathologic features and also to assess their relevance. Materials and Methods: Retrospective analysis of the data retrieved was done for 74 cases of nerve biopsies. Results: On the basis of the data and histopathological features, broad diagnoses were obtained in 52 cases and further categorized into biopsies being supportive for patient management (including acute and chronic axonopathies and demyelinating neuropathies) and biopsies considered essential for patient management (including vasculitic neuropathies, leprous neuropathies, hereditary neuropathies, and chronic inflammatory demyelinating neuropathies). Nine nerve biopsies did not show any abnormal histopathological features, while 13 nerve biopsies were found to be inadequate for diagnosis, both these groups were categorized as noncontributory. Conclusion: With advanced nerve conduction studies available, nerve biopsy is losing its relevance. However, in our experience, nerve biopsy did complement the clinical findings and nerve conduction studies, with which a close correlation is required to make the histopathology of nerve biopsy more relevant in terms of guiding further specific workup and management.
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The present study aimed to investigate the antidiabetic effect of alcoholic seed extract of Aegel marmelos in comparison with glibenclamide in in vivo using alloxan rat model.The diabetic rats were orally given glibenclamide and alcoholic seed extract of Aegle marmelos for 21 days. The effects were studied in vivo. Oral administration of alcoholic seed extract of Aegle marmelos decrease the level of serum glucose, total cholesterol (TCH), triglycerides(TG), low density lipoprotein (LDLP), very low density lipoprotein(VLDLP) significantly while increasing HDL-cholesterol. Alcoholic seed extract of Aegle marmelos was also evaluated for oral glucose tolerance(OGTT) characteristics. In conclusion, alcoholic seed extract of Aegle marmelos had potential antidiabetic activity. Further it has been observed that the seed extract have positive effect on liver & kidney parenchyma.
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Traditional Systems of medicines always played important role in the global health. In the traditional health medicinal plants providing a new areas of drug research. The demand for plant based medicines, food supplement, health products, pharmaceuticals and cosmetics are increasing in both developing and developed countries due to the growing recognition that the natural products are non toxic, have less side effects and easily available. Leptadenia pyrotechnica (Forsk.) commonly known as Kheep belonging to family Asclepiadaceae. Leptadenia pyrotechnica leafless much branched shrub. All parts of Leptadenia pyrotechnica are used in traditional medicines. The present article gives an account of updated information on its phytochemistry pharmacological properties. Ethnomedical uses say to possess significant antioxidant, anti-inflammatory, antibacterial, anthelmentic, antilipoxygenase, cytotoxic, antitumour, hypolipidemic and anti atherosclerotic activity. The present review contains wide number of isolated chemical constituents and various ethnomedical and traditional uses of Leptadenia pyrotechnica. It include information about historical background, conceptual basis, different disciplines studied in the systems, research and development aspects, drug manufacturing aspects and impact of globalization.
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The seeds of Benincasa hispida commonly known as ash gourd belonging to Cucurbitaceae family is employed as a main ingredient in kusmanda lehyam in Ayurvedic system of medicine. The seeds of Benincasa hispida mashed with milk or the various preparations from the pulp of fruit in the form of sweetmeats, like Kusmanda paka and petha are commonly used as a general tonic, aphrodisiac, rejuvenative and also a brain tonic. The plant of Benincasa hispida was collected from (Central Council for Research in Ayurveda & Siddha, Dept. of ayush, Ministry of Health & F.W, Govt. of India New Delhi) Govt. Central Pharmacy Annex, Ashoka Pillar, Jayanagar Bangalore. The extracts were subjected to Antioxidant activity by In hydrogen peroxide-scavenging model, model acetone extract showed scavenging (80.1%) of hydrogen peroxide and chloroform extract showed ( 79%) in comparison with ascorbic acid ( 94.5% ). Antioxidant activity was carried out for extract (acetone, chloroform, and aqueous extracts) with Hydrogen peroxide-scavenging model. Acetonic extract showed more scavenging (80.1%) of Benincasa hispida and least scavenging was done by aqueous extract of (43%). After comparison with the standard drug (Ascorbic acid) showed (94.5%). From this it was conclused that acetone extract of Benincasa hispida showed high scavenging activity. Conclusively, the result revealed that Benincasa hispida seeds has antimicrobial activity & antioxidant activity which may be due to the presence of alkaloids, phenolic compounds, flavonoids constituents present in the sample.