Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines / 中国中药杂志

To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.

Optimization of formulation of Fufang Danshen immediate release tablet by colligation score / 中国中药杂志

<p><b>OBJECTIVE</b>To optimize the formulation of immediate release tablet.</p><p><b>METHOD</b>The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.</p><p><b>RESULT</b>The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.</p><p><b>CONCLUSION</b>It is successful to prepare on immediate release tablet using the optimized formula above.</p>