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1.
Chinese Medical Journal ; (24): 3874-3878, 2013.
Artículo en Inglés | WPRIM | ID: wpr-236146

RESUMEN

<p><b>BACKGROUND</b>Intramedullary nails had been widely used in the treatment of long-bone fractures because of less interference of fractures and center bearing biomechanical advantage. However, it had been also found many shortcomings such as broken nails, delayed healing and was modified in order to achieve better efficacy and reduce complications. The aim of the present study is to compare the efficacy of rotary self-locking intramedullary nails (RSIN) with that of interlocking intramedullary nails (IIN) in the treatment of long-bone fractures.</p><p><b>METHODS</b>A retrospective study investigated 129 cases with long-bone fractures (36 with femoral fracture, 81 with tibial fracture, and 12 with humeral fracture). The fractures were fixed using either an RSIN or IIN. All patients underwent followup for 12-30 months.</p><p><b>RESULTS</b>All patients in both groups achieved a clinical fracture healing standard and the postoperative affected limb muscle strength and joint function were well restored. The RSIN group required a shorter operative time and the fracture healed faster. There was no significant difference in the hospital stay, intraoperative blood loss or postoperative complications between the two groups.</p><p><b>CONCLUSIONS</b>RSIN is used to treat long-bone fractures. Its healing efficacy is equivalent to the IIN. Moreover, the RSIN method is simpler and causes less tissue damage than the IIN, therefore having the advantage of accelerated healing.</p>


Asunto(s)
Femenino , Humanos , Masculino , Clavos Ortopédicos , Fracturas del Fémur , Cirugía General , Curación de Fractura , Fisiología , Fracturas del Húmero , Cirugía General , Estudios Retrospectivos , Fracturas de la Tibia , Cirugía General
2.
Chinese Medical Journal ; (24): 1590-1592, 2011.
Artículo en Inglés | WPRIM | ID: wpr-353936

RESUMEN

Migration of a bullet to a distant part of the body after a gunshot is rarely observed in the clinical setting, and migration to the heart is even rarer. There are usually no clear symptoms or signs from migration of a bullet. The bullet can be easily missed and sometimes identified in a review examination. A case of bullet migration to the heart 2 months after a gunshot to the left knee was reported.


Asunto(s)
Adulto , Humanos , Masculino , Lesiones Cardíacas , Patología , Rodilla , Patología , Heridas por Arma de Fuego
3.
China Journal of Chinese Materia Medica ; (24): 1015-1017, 2006.
Artículo en Chino | WPRIM | ID: wpr-351795

RESUMEN

<p><b>OBJECTIVE</b>To investigate the effect of andrographolide on virulence factors production in Pseudomonas aeruginosa.</p><p><b>METHOD</b>Growth rate, pyocyanin, proteolytic activity and elastase activity were measured with or without the presence of andrographolide. The effect of andrographolide on pyocyanin production, proteolytic activity and elastase activity in PAO-JP2 was investigated simultaneously.</p><p><b>RESULT</b>The andrographolide did not affect the growth of PAO1 in planktonic culture. The production of pyocyanin, proteolytic activity and elastase activity were significanthy suppressed in P. aeruginosa cultures grown in the presence of andrographolide. However, these effects were not observed in PAO-JP2.</p><p><b>CONCLUSION</b>The inhibiting effect of andrographolide on virulence factors production in P. aeruginosa may play a role in its anti-infection activity.</p>


Asunto(s)
Andrographis , Química , Antibacterianos , Farmacología , Diterpenos , Farmacología , Elastasa Pancreática , Metabolismo , Péptido Hidrolasas , Metabolismo , Plantas Medicinales , Química , Pseudomonas aeruginosa , Metabolismo , Virulencia , Piocianina , Metabolismo , Factores de Virulencia , Metabolismo
4.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 422-426, 2004.
Artículo en Chino | WPRIM | ID: wpr-326732

RESUMEN

<p><b>OBJECTIVE</b>To explore the mechanism of anisodamine in treating infectious shock through studying effect of anisodamine on endotoxin lipopolysaccharide (LPS) induced expression of tissue factor (TF) and plasminogen activator inhibitor type 1 (PAI-1) in vascular endothelial cells (EC).</p><p><b>METHODS</b>Human umbilical vein endothelial cells (HUVEC) were cultured by trypsin digestion method. PAI-1 was measured in the conditioned medium of HUVEC by a specific enzyme-linked immunosorbent assay (ELISA), whereas TF activity was measured in the lysates of these cells by using a single step clotting assay. Specific mRNA expressions were determined by Northern blotting. In order to evaluate a possible contribution of the nuclear factor-kappa B (NF-kappa B) pathway on the transductive effects observed, electrophoretic mobility shift assays (EMSA) were performed using nuclear extracts from HUVEC and NF-kappa B binding oligonucleotides.</p><p><b>RESULTS</b>LPS could significantly strengthen the expression of HUVEC PAI-1 protein and TF activity and its mRNA, this effect of LPS could be markedly weakened after adding Anisodamine dose-dependently. Anisodamine could also completely block the LPS induced NF-kappa B DNA binding activity in nuclear extracts from HUVEC.</p><p><b>CONCLUSION</b>The possible mechanism of anisodamine in treating infectious shock may be through antagonizing LPS induced HUVEC TF and PAI-1 expression, and the antagonism might be, at least partially, transduced by path of NF-kappa B.</p>


Asunto(s)
Humanos , Células Cultivadas , Medios de Cultivo Condicionados , Medicamentos Herbarios Chinos , Farmacología , Células Endoteliales , Biología Celular , Metabolismo , FN-kappa B , Metabolismo , Inhibidor 1 de Activador Plasminogénico , Genética , ARN Mensajero , Genética , Alcaloides Solanáceos , Farmacología , Tromboplastina , Genética , Venas Umbilicales , Biología Celular
5.
Chinese Journal of Infectious Diseases ; (12)2001.
Artículo en Chino | WPRIM | ID: wpr-679838

RESUMEN

Objective To develop a real-time polymerase chain reaction(PCR)system to determine transcriptional level of MexAB-OprM multidrug efflux pump gene and to investigate the impact of androgra- pholide on MexAB-OprM gene transcription in Pseudomonas aeruginosa.Methods The fragments of mexB gene of mexAB-oprM operon and 30S rRNA gene rpsL were amplified and cloned into two plas- mids respectively.These plasmids were used as external standards for real-time PCR.Real-time PCR was applied to measure the mRNA transcripition of mexB and rpsL gene in Pseudomonas aeruginosa growing in medium with different concentrations of andrographolide.Results The plasmids for standard curve were constructed successfully.The relative mexB mRNA expressions in 50,100,150 and 200?g/mL andrographolide were 0.04?0.03,0.06?0.07,0.09?0.03 and 0.04?0.03 respectively, which were significantly lower than that in the control(0.24?0.04,P0.05).Conclusion Andrographolide can reduce the transcriptional level of MexAB-OprM,which may he one mechanism for its anti-infection effect.

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