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Journal of Central South University(Medical Sciences) ; (12): 430-433, 2006.
Artículo en Chino | WPRIM | ID: wpr-813679

RESUMEN

OBJECTIVE@#To determine the influence and significance of intermittent ventilation on lung cytokines during cardiopulmonary bypass (CPB).@*METHODS@#Thirty-six patients with rheumatic heart disease (RHD) were divided into 2 groups randomly: Treatment group (n = 18, given intermittent ventilation once every 5 minutes during CPB; control group ( n = 18), no ventilation during CPB. A brochioalveolar lavage was performed at 2 hours after the CPB. The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH in the brochioalveolar lavage fluids were measured, and lung PaO2/FiO2 were measured preoperatively and at 1 hour, 4 hours, and 8 hours after the CPB termination.@*RESULTS@#The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH of the treatment group in the brochioalveolar lavage fluids were significantly lower than those of the control group (P < 0.05), and the lung PaO2/FiO2 of the treatment group at 1 hour, 4 hours, and 8 hours after the CPB termination significantly increased than those of the control group (P < 0.05). A significant decrease of lung PaO2/FiO2 occurred in both groups at 1 hour, 4 hours, and 8 hours after the CPB compared with the same group at the baseline before the CPB (P < 0.01).@*CONCLUSION@#Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Puente Cardiopulmonar , Citocinas , Metabolismo , Interleucina-1 , Metabolismo , Interleucina-6 , Metabolismo , Respiración con Presión Positiva Intermitente , Pulmón , Metabolismo , Cardiopatía Reumática , Cirugía General , Factor de Necrosis Tumoral alfa , Metabolismo
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