RESUMEN
OBJECTIVE:To study the impact of amoxicillin on dysmenorrhea model mice treated with paeoniflorin.METHODS:The enrolled mice were randomized to different groups and all were given diethylstilbestrol i.g.for 12 consecutive days.From day 5 to day 12,the model control(MC)group,positive control(PC)group and 3 PA groups(different dosage of paeoniflorin plus amoxicillin)were given amoxicillin i.g.On day 12,3 P(paeoniflorin)groups and 3 PA groups were respectively given different dosage of paeoniflorin i.g.All groups were respectively given oxytocin i.p 1 hour after medication.The incubation period(TIP,seconds)between oxytocin i.p.and the first time of body twisting and the number of the body twisting(NBT)in 15 minutes of the mice were recorded.RESULTS:Compare to NC(negative control)and MC groups,the TIP was significantly prolonged and the NBT in 15min were significantly decreased in 3 P groups(P0.05).CONCLUSION:The curative effect of paeoniflorin in treating dysmenorrheal model mouse was decreased by amoxicillin suggests that the 2 drugs were unsuitable to be used concomitantly.