RESUMEN
Several experiments were conducted to explore the relation between acupuncture manipulations and needling sensations based on M-QNS by describing needling intensity at quantification. The results indicated that the relation between acupuncture manipulations and peak value of needling sensation could not be confirmed when needling intensity and electric intensity were variables, and the peak value of needling sensation produced by manipulations should be a random variable under a certain circumstance. Sham acupuncture didn’t necessarily mean absence of stimulating intensity. Therefore, the subjects of acupuncture-moxibustion and medication are kind of heterogeneous, while acupuncture research should adopt observation of needling sensation and the peak value of needling sensation as the major research method as the basic action mechanism of acupuncture mainly involves neuroscience.