RESUMEN
OBJECTIVE:To prepare compound fluorouracil gel and to establish a method for its quality control.METHODS:Carbomer-940 was used as base material to prepare the compound fluorouracil gel.The content determination of fluorouracil and hydrocortisone was performed by RP-HPLC,and the stability and irritability of this preparation were investigated as well.RESULTS:The gel prepared was well-distributed,with property,identification and tests all in conformity with the description of China Pharmacopeia(2005 edition).The good linear ranges of fluorouracil and hydrocortisone were 0.06～ 0.14mg? mL-1(r=0.999 8)and 0.006～ 0.014mg? mL-1(r=0.999 9),respectively,and the average recovery rates of whi-ch were 100.70%(RSD=0.51%)and 99.88%(RSD=0.83%),respectively.The gel remained stable after storing for 6mo at room temperature away from light,and there was no significant difference in irritability as compared with blank base material.CONCLUSION:The preparation technique of compound fluorouracil gel is simple and practicable,and its quality is reliable.
RESUMEN
OBJECTIVE： To prepare Kangzhi lotion and observe its therapeutic effects on seborrheic dermatitis METHODS： To introduce the ingredients， preparation process and quality control of the lotion RESULTS:The total effective rate of the lotion on seborrheic dermatitis was 90 5％ CONCLUSION： The product is reliable in clinical effect and does not induce adverse reaction