Dual roles of Nrf2 in tumorigenesis / 中华地方病学杂志

Activation of the transcription factor NF-E2-related factor 2 (Nrf2)-signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to chemical carcinogenesis and other forms of toxicity. However, overexpression of Nrf2 has been recognized to promote oncogenesis and resistance to chemotherapy. The application of Nrf2 in tumor chemoprevention and treatment has also become a hot topic. This review focuses on the dual roles of Nrf2 in tumorigenesis and the application of Nrf2 in tumor chemoprevention and treatment.