RESUMEN
Objective To explore the association between single nucleotide polymorphism(SNPs)of eNOS gene T -786C and G894T and the risk of coronary heart disease (CHD).Methods Genotypes of single nucleotide polymorphism (SNPs)of eNOS gene T -786C and G894T were detected in 842 CHD patients and 842 age and gender matched healthy control individuals using Taqman -polymerase chain reaction genotyping assay and the association between them were analyzed.Results Genotype distributions of the two loci in controls were in consistence with Hardy -Weinberg inheritance model.Frequencies of allele C (8.79% vs.6.53%,P =0.01 4,OR =2.54,95%CI =2.01 -3.1 4),CC (0.84% vs. 0.1 1 %,P =0.04,OR =3.81 ,95%CI =1 .74 -5.56)and TC /CC (1 6.75% vs.1 3.06%,P =0.03,OR =2.1 1 ,95%CI =1 .75 -2.98)genotypes in cases were obviously higher than in controls.However,there was no significant frequency difference of TC genotype in two groups.No significant association was found between allele T,genotype GT,TT and GT/TT and the risk of CHD.Conclusion Allele C,genotype CC and TC /CC of T -786C within eNOS gene were statistically significantly associated with increased risk of CHD,indicating that this locus might be involved in the pathological process of CHD,and allele C,genotype CC,TC /CC might be genetic susceptible factors for CHD.