RESUMEN
The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L.
Asunto(s)
Animales , Ratones , Antiinflamatorios , Química , Farmacología , Medicamentos Herbarios Chinos , Química , Inhibidores Enzimáticos , Química , Farmacología , Etanol , Química , Flores , Química , Lonicera , Química , Macrófagos , Metabolismo , Estructura Molecular , Óxido Nítrico , Metabolismo , Óxido Nítrico Sintasa de Tipo II , Extractos Vegetales , Química , Plantas Comestibles , Química , Triterpenos , Química , FarmacologíaRESUMEN
Cyclic lipopeptide, also named as acylpeptide, which was characteristic with novel structures, was paid more attention in the recent years. Cyclic lipopeptide showed various bioactivities including antibacterial, anti-tumor, anti-inflammatory, etc. Cyclic lipopeptide originated mainly from the second metabolites of microorganism, such as Cyanobacterium, Bacterium, Actinomyces, etc. The bacteria included the genus of Bacillus and Pseudomonas. In this account, the review has been made on the development of cyclic lipopeptide.