RESUMEN
Cryptococcosis is a cosmopolitan infectious disease of man and animal resulting from the inhalation or ingestion of the encapsulated potentially pathogenic fungus Cryotococcus neoformans that can be isolated from many common environmental sources. The respiratory tract is considered to be the primany portal of entry. Following invasion of the lungs, the organism may become localized or may be disseminated hematogenously to any aprt of the body, especially the brain, meninges and cord. The patients withe malignant reticuloendothelial neoplasms; Hodgkin's disease, lymphowarcoma, leukemia and diabetes, and those receiving prolonged therapy with steroids were particularly susceptible to disease with Cryptococcus neoformans, We experienced a case of Cryptococcosis in 22 months old Korean boy which was confirmed histologically from lymphnode biopsy. Also we made a brief review of literatures.