Bacterial communities associated with an occurrence of colored water in an urban drinking water distribution system / 生物医学与环境科学（英文）

This study aimed to investigate bacterial community in an urban drinking water distribution system (DWDS) during an occurrence of colored water. Variation in the bacterial community diversity and structure was observed among the different waters, with the predominance of Proteobacteria. While Verrucomicrobia was also a major phylum group in colored water. Limnobacter was the major genus group in colored water, but Undibacterium predominated in normal tap water. The coexistence of Limnobacter as well as Sediminibacterium and Aquabacterium might contribute to the formation of colored water.

Risk factors for the development of vaginal intraepithelial neoplasia / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Vaginal intraepithelial neoplasia (VAIN), as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population.</p><p><b>METHODS</b>A case-control study was conducted, including 63 VAIN cases and 64 healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus (HPV) status.</p><p><b>RESULTS</b>Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women (95%CI: 1.10 - 3.85; P = 0.024). The patients with previous hysterectomy had an increased risk of VAIN (OR = 4.69; P = 0.003). Patients with a history of cervical cancer or CIN were predisposed to VAIN (OR = 78.75; P < 0.0001). The rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load (OR = 126.00; P = 0.000). Multivariate analysis showed that HPV infection and a history of CIN or cervical cancer were still found to be significant in patients.</p><p><b>CONCLUSION</b>HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN.</p>