Variability in reference for serum metabolomics profiles among healthy Han people in different regions of China / 中华内分泌代谢杂志

Objective:To establish the reference for serum metabolomics profiles among healthy Han adults in China, and explore the variation on metabolomics profiles by geographic regions, sex, and age.Methods:Cross-sectional data and serum samples were obtained from the China National Health Survey. A total of 1 039 male and 1 032 female healthy adults(≥30 years) were included in this study. Serum metabolomics analyses were conducted with ultra-performance liquid chromatography-mass spectrometry(UPLC-MS). Orthogonal partial least squares discriminant analysis(OPLS-DA) was performed to compare the differences of metabolomics among different region, sex, and age.Results:Significant differences on metabolomics profiles were identified among region, sex, and age. A total of 114 region-related metabolites were spotted, including 53 metabolites that involved in human metabolic pathways, mainly peptides(20 metabolites) and glycerophospholipid metabolism-related(14 metabolites). Fifty-nine metabolites were pinned down to be sex-related, among which cotinine was significant in all 7 provinces. Age-related metabolites were only found in Shaanxi and Hainan, with 22 metabolites were recognized.Conclusion:Serum metabolomics varies by geographic regions, sex, and age. When metabolomics is applied for diagnosis or biomarker screening in various studies, it shall take into consideration of setting tailored references.

Effect of transversus abdominis plane block on postoperative cognitive function in elderly patients undergoing laparoscopic surgery under general anesthesia / 中华麻醉学杂志

Objective To evaluate the effect of transversus abdominis plane (TAP) block on postoperative cognitive function in elderly patients undergoing laparoscopic surgery under general anesthesia.Methods Forty-eight male patients undergoing laparoscopic tension-free repair of inguinal hernia under general anesthesia,aged 65-75 yr,of American Society of Anesthesiologists physical status Ⅱ or Ⅲ,with body mass index of 20-28 kg/m2,were divided into 2 groups (n =24 each) using a random number table method:TAP block combined with general anesthesia group (group TG) and general anesthesia group (group G).Anesthesia was induced with midazolam,cisatracurium besylate,sufentanil and etomidate,and the patients were mechanically ventilated after laryngeal mask airway insertion.TAP block was performed through the anterior superior iliac spine approach,and 0.25％ ropivacaine 30 ml was injected in group TG.Anesthesia was maintained by target-controlled infusion of propofol and remifentanil and muscle relaxation by intravenously injecting cisatracurium.The occurrence of cerebral regional oxygen saturation (rSO2) and low rSO2 events (rSO2 ＜60％) was recorded at 1 min before anesthesia induction (T0),5 min after inserting the laryngeal mask airway (T1),at skin incision (T2),30 min after skin incision (T3),and at the end of surgery (T4).The consumption of propofol and remifentanil was recorded during surgery.Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive function of patients at 1 day before surgery and 7 days after surgery,and the development of postoperative cognitive dysfunction (POCD,MoCA scores＜ 26) was recorded.Results Compared with group G,the intraoperative consumption of propofol and remifentanil was significantly reduced,rSO2 was increased at T2~,and the incidence of low rSO2 events was decreased,MoCA scores were increased at 7 days after surgery,and the incidence of POCD was decreased in group TG (P＜0.05).Conclusion TAP block can reduce the incidence of POCD in elderly patients undergoing laparoscopic surgery under general anesthesia.

Relationship among aggressive trait,patient-physician trust and illness perception of patients / 中华行为医学与脑科学杂志

Objective To investigate the relationship between aggressive trait of patients,patient-physician trust and illness perception. Methods Totally 500 patients were recruited from different medical departments from eight hospitals in Guangdong and 384 samples' valid data were obtained. The aggressive trait of patients,patient-physician trust and illness perception were assessed with the Buss-Perry aggression questionnaire( BPAQ), the Wake Forest physician trust scale ( WFPTS), and the brief illness perception questionnaire(BIPQ) respectively. SPSS 23. 0 and AMOS 20. 0 were used for data analysis and structural e-quation model construction. Results Pearson correlation analysis showed that the BPAQ (53. 2±13. 9) and BIPQ(38. 6±9. 1) were negatively correlated respectively with WFPTS (35. 3±6. 1) and benevolence (17. 6 ±3. 2) and technical competence (17. 8±3. 3),(r=-0. 14~-0. 18,P<0. 01). And there was positive corre-lation between BPAQ scores and BIPQ score(r=0. 37,P<0. 01). Mediation effect test showed that patient-physician trust mediated the associations between patient aggression and illness perception (B=0. 039,95% CI= (0. 002,0. 120)). Conclusion Aggressive trait and patient-physician are significantly related with ill-ness perception. Patient-physician trust exerts mediating effect on the relationship between aggression of pa-tients and illness perception.

Effect of maximum blood pressure fluctuation on prognosis of patients with acute ischemic stroke within 24 hours after hospital admission / 中华流行病学杂志

Objective To investigate the relationship between the maximum blood pressure fluctuation within 24 hours after admission and the prognosis at discharge.Methods The patients with ischemic stroke admitted in Department of Neurology of the First Affiliated Hospital of Harbin Medical University within 24 hours after onset were consecutively selected from April 2016 to March 2017.The patients were grouped according to the diagnostic criteria of hypertension.Ambulatory blood pressure of the patients within 24 hours after admission were measured with bedside monitors and baseline data were collected.The patients were scored by NIHSS at discharge.The relationships between the maximum values of systolic blood pressure (SBP) or diastolic blood pressure (DBP) and the prognosis at discharge were analyzed.Results A total of 521 patients with acute ischemic stroke were enrolled.They were divided into normal blood pressure group (82 cases) and hypertension group (439 cases).In normal blood pressure group,the maximum values of SBP and DBP were all in normal distribution (P＞0.05).The maximum value of SBP fluctuation was set at 146.6 mmHg.After adjustment for potential confounders,the OR for poor prognosis at discharge in patients with SBP fluctuation ≥146.6 mmHg was 2.669 (95％ CI:0.594-11.992) compared with those with SBP fluctuation ＜ 146.6 mmHg.The maximum value of DBP fluctuation was set at 90.0 mmHg,and the adjusted OR for poor prognosis at discharge in patients with DBP fluctuation ≥90.0 mmHg was 0.416 (95％ CI:0.087-1.992) compared with those with DBP fluctuation ＜90.0 mmHg.In hypertension group,the maximum values of SBP and DBP were not in normal distribution (P＜0.05).The maximum value of SBP fluctuation was set at median 171.0 mmHg.After adjustment for the confounders,the greater the maximum of SBP,the greater the risk of poor prognosis at discharge was,the OR was 1.636 (95％CI:1.014-2.641).The maximum value of DBP fluctuation was set at median 98.0 mmHg.After adjustment for the confounders,the greater the maximum of DBP,the greater the risk of poor prognosis at discharge was,the OR was 1.645 (95％CI:1.003-2.697).Conclusion In acute ischemic stroke patients with normal blood pressure at admission,the maximum values of SBP and DBP within 24 hours after admission had no relationship with prognosis at discharge.In acute ischemic stroke patients with hypertension at admission,the maximum values of SBP and DBP within 24 hours after admission were associated with poor prognosis at discharge.

Effect of maximum blood pressure fluctuation on prognosis of patients with acute ischemic stroke within 24 hours after hospital admission / 中华流行病学杂志

Objective To investigate the relationship between the maximum blood pressure fluctuation within 24 hours after admission and the prognosis at discharge.Methods The patients with ischemic stroke admitted in Department of Neurology of the First Affiliated Hospital of Harbin Medical University within 24 hours after onset were consecutively selected from April 2016 to March 2017.The patients were grouped according to the diagnostic criteria of hypertension.Ambulatory blood pressure of the patients within 24 hours after admission were measured with bedside monitors and baseline data were collected.The patients were scored by NIHSS at discharge.The relationships between the maximum values of systolic blood pressure (SBP) or diastolic blood pressure (DBP) and the prognosis at discharge were analyzed.Results A total of 521 patients with acute ischemic stroke were enrolled.They were divided into normal blood pressure group (82 cases) and hypertension group (439 cases).In normal blood pressure group,the maximum values of SBP and DBP were all in normal distribution (P＞0.05).The maximum value of SBP fluctuation was set at 146.6 mmHg.After adjustment for potential confounders,the OR for poor prognosis at discharge in patients with SBP fluctuation ≥146.6 mmHg was 2.669 (95％ CI:0.594-11.992) compared with those with SBP fluctuation ＜ 146.6 mmHg.The maximum value of DBP fluctuation was set at 90.0 mmHg,and the adjusted OR for poor prognosis at discharge in patients with DBP fluctuation ≥90.0 mmHg was 0.416 (95％ CI:0.087-1.992) compared with those with DBP fluctuation ＜90.0 mmHg.In hypertension group,the maximum values of SBP and DBP were not in normal distribution (P＜0.05).The maximum value of SBP fluctuation was set at median 171.0 mmHg.After adjustment for the confounders,the greater the maximum of SBP,the greater the risk of poor prognosis at discharge was,the OR was 1.636 (95％CI:1.014-2.641).The maximum value of DBP fluctuation was set at median 98.0 mmHg.After adjustment for the confounders,the greater the maximum of DBP,the greater the risk of poor prognosis at discharge was,the OR was 1.645 (95％CI:1.003-2.697).Conclusion In acute ischemic stroke patients with normal blood pressure at admission,the maximum values of SBP and DBP within 24 hours after admission had no relationship with prognosis at discharge.In acute ischemic stroke patients with hypertension at admission,the maximum values of SBP and DBP within 24 hours after admission were associated with poor prognosis at discharge.

Axial Movements and Length Changes of the Human Lower Esophageal Sphincter During Respiration and Distension-induced Secondary Peristalsis Using Functional Luminal Imaging Probe

BACKGROUND/AIMS: Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a scarcity of technology for measuring esophagus movements in the longitudinal (axial) direction. The aim of this study is to develop new analytical tools for dynamic evaluation of the length change and axial movement of the human LES based on the functional luminal imaging probe (FLIP) technology and to present normal signatures for the selected parameters. METHODS: Six healthy volunteers without hiatal hernia were included. Data were analyzed from stepwise LES distensions at 20, 30, and 40 mL bag volumes. The bag pressure and the diameter change were used for motion analysis in the LES. The cyclic bag pressure frequency was used to distinguish dynamic changes of the LES induced by respiration and secondary peristalsis. RESULTS: Cyclic fluctuations of the LES were evoked by respiration and isovolumetric distension, with phasic changes of bag pressure, diameter, length, and axial movement of the LES narrow zone. Compared to the respiration-induced LES fluctuations, peristaltic contractions increased the contraction pressure amplitude (P < 0.001), shortening (P < 0.001), axial movement (P < 0.001), and diameter change (P < 0.01) of the narrow zone. The length of the narrow zone shortened as function of the pressure increase. CONCLUSIONS: FLIP can be used for evaluation of dynamic length changes and axial movement of the human LES. The method may shed light on abnormal longitudinal muscle activity in esophageal disorders.

Effect of self-control training on depressive disorders in college students / 中国心理卫生杂志

Objectives:To design a self-control training program based on the recent findings of self-control and self-regulation after taking full consideration of the unique characteristics of depression disorder,with an emphasis on behavioral activation and reinforcement.Methods:Totally 46 students who were diagnosed with major depression were randomly assigned to one of the two groups:Group 1 (n =23),and Group 2 (n =23).Participants in the Group 1 received 24-week self-control training program,as compared to Group 2 who received only baseline and post-24-week-intervention measurements,the measurements included Self-control Scale (SCS) and Beck Depression Inventory (BDI-Ⅱ).The self-control training included eight-week training modules and 16-week consolidation module.Results:In Group 1,the SCS scores were higher in post-intervention than in baseline measurement [(38.0 ± 6.3) vs.(34.7 ± 8.2),P ＜ 0.01],and the BDI-Ⅱ scores were lower in post-intervention than in baseline measurement [(19.0 ± 6.1) vs.(21.8 ± 4.8),P＜0.01] in Group 1.Whereas in Group 2,there were no significant differences between baseline and post-24-week-intervention measurements of SCS and BDI-Ⅱ scores (Ps ＞0.05).Conclusion:The study provides new evidence for the self-regulation model of depression.Self-control training could be an effective intervention strategy for the treatment of depression.

Chain mediating effect of mindfullness and sleep quality between negative life events and depression among college students / 中华行为医学与脑科学杂志

Objective To explore the role of mindfullness in the negative life events,depression,and poor sleep quality.Methods Using five facet mindfullness questionnaire(FFMQ),adolescents self-rating life events checklist (ASLEC),self-rating depression scale (SDS) and Pittsburgh sleep quality index (PSQI) to investigate 2 792 freshmen in a medical university in Guangzhou.Results The FFMQ score (126.02±12.14) was negatively correlated with ASLEC score(23.93±19.81),SDS score(35.89±7.31) and PSQI score (3.45±2.13) (r=-0.17,r=-0.44,r=-0.26,P＜0.01).The boys in the aspects of " mindfullnessinaction" scored significantly higher than that of girls (21.20 ± 3.36,20.52±2.88,P＜0.01).The girls scored significantly higher than boys in the PSQI,SDS (3.58±2.15,3.21 ±2.08,P＜0.05;36.22±7.26,35.27±7.35,P＜0.01).Mindfullness and sleep quality showed a chain-mediated effect between negative life events and depression,and the model fitting was good (RMSEA =0.048,CFI =0.962,TLI =0.943).The total mediating effect size was 61.41％.The mediating path through mindfullness,with the effect size of 16.71％,and the chain-mediating effect was 8.94％.Conclusion The higher the level of mindfullness,the lower the individual's depression score and the better the quality of sleep.Mindfullness and the sleep quality play a role of chain-mediating effect between negative life events and depression.

Chain mediating effect of mindfullness and sleep quality between negative life events and depression among college students / 中华行为医学与脑科学杂志

Objective To explore the role of mindfullness in the negative life events,depression,and poor sleep quality.Methods Using five facet mindfullness questionnaire(FFMQ),adolescents self-rating life events checklist (ASLEC),self-rating depression scale (SDS) and Pittsburgh sleep quality index (PSQI) to investigate 2 792 freshmen in a medical university in Guangzhou.Results The FFMQ score (126.02±12.14) was negatively correlated with ASLEC score(23.93±19.81),SDS score(35.89±7.31) and PSQI score (3.45±2.13) (r=-0.17,r=-0.44,r=-0.26,P＜0.01).The boys in the aspects of " mindfullnessinaction" scored significantly higher than that of girls (21.20 ± 3.36,20.52±2.88,P＜0.01).The girls scored significantly higher than boys in the PSQI,SDS (3.58±2.15,3.21 ±2.08,P＜0.05;36.22±7.26,35.27±7.35,P＜0.01).Mindfullness and sleep quality showed a chain-mediated effect between negative life events and depression,and the model fitting was good (RMSEA =0.048,CFI =0.962,TLI =0.943).The total mediating effect size was 61.41％.The mediating path through mindfullness,with the effect size of 16.71％,and the chain-mediating effect was 8.94％.Conclusion The higher the level of mindfullness,the lower the individual's depression score and the better the quality of sleep.Mindfullness and the sleep quality play a role of chain-mediating effect between negative life events and depression.

Mediation effect of perceived social support between aggression of patients and doctor-patients trust / 中华行为医学与脑科学杂志

Objective To explore the relationship among aggression of patients,doctor-patient trust and perceived social support,and to provide a new prospective of improving doctor-patient relationship.Methods Data of Chinese buss-perry aggression scale,wake forest physician trust scale and perceived social support were collected from a sample of 338 patients in Guangzhou and analyzed with structural equation modeling.Results ①Median (interquartile range) of aggression,doctor-patient trust and perceived social support were 54(18),32(8) and 62(15) respectively.②Total score of aggression(Z=-2.37,P=0.02) and the dimension score of physical-aggression(Z=-4.07,P＜0.01) between different gender were statistically significant,and the scores of male were higher than female.③According to relevant result,aggression of patients was significantly negatively correlated with both doctor-patient trust (r=-0.13,P＜0.05)and perceived social support(r=-0.14,P＜0.01).Doctor-patient trust was significantly positively correlated with perceived social support(r=0.36,P＜0.01) ④Perceived social support fully mediate the relationship between aggression of patients and doctor-patient trust(GFI =0.989,NFI =0.989,IFI =0.998,CFI =0.998,RMSEA =0.026,x2/df=1.229).Conclusion Perceived social support is a protective factor of aggression of patients.Improving the perceived social support of patients can promote the doctor-patient trust.

Prospective cohort study on the relationship between smoking cessation and cancer risk in males / 中华预防医学杂志

<p><b>OBJECTIVE</b>To investigate the effect of smoking cessation on the risk of cancer among male subjects.</p><p><b>METHODS</b>Participants of this study were derived from the workers in Kailuan Group who took the health check-up examination in its 11 affiliated hospitals. The check-up examinations were given biennially based on uniformed standard. From May 2006 to December 2011, health examinations were given for 3 rounds and a total of 104 809 male workers involved. The date of being enrolled in this study was defined as that of taking first check-up, and the date of end-of-observation was defined as that of cancer diagnosis, death or end of follow-up.</p><p><b>INCLUSION CRITERIA</b>age ≥18 while being enrolled in this study, and there was no information missing in the questionnaire for age (or date of birth), smoking status, the age of starting smoking, the age of quitting smoking, and smoking amount. The information of smoking status was collected by questionnaires, and the information of newly-diagnosed cancer cases was obtained by follow-up. After adjusted for age, education background, drinking habits, working environment and BMI, multi-variate Cox proportional hazard regression models were used to analyze the association between smoking cessation and cancer risk (all sites of cancers, smoking-related cancers, and lung cancer) by calculating the values of HR (hazard ratio) and 95% CI (confidence interval).</p><p><b>RESULTS</b>Totally, 104 809 subjects were followed up for 450 639.6 person-years, including 46 013 smokers (43.90%), 51 624 never-smokers (49.26%), and 7 172 smoking quitters (6.84%). Among all these subjects, 1 323 were diagnosed as cancer cases, including 1 082 smoking-related cancers, of which 378 were lung cancer cases. The results showed that, compared with never-smokers, smokers had increased risks for all sites of cancers (HR=1.38, 95% CI: 1.20- 1.59), smoking-related cancers (HR=1.45, 95% CI: 1.24- 1.69) and lung cancer (HR=1.70, 95% CI: 1.31- 2.21). While compared with the smokers, smoking quitters had decreased risk of lung cancer (HR=0.36, 95% CI: 0.20- 0.65). For the smokers with smoking history ≥20 pack-years, HR (95% CI) of lung cancer incidence was 0.09 (0.01- 0.65). For people age ≥60 smoke quitter, HR (95% CI) of lung cancer incidence was 0.33 (0.16- 0.68). For people who quit ≥10 years, HR (95% CI) of lung cancer incidence was 0.19(0.06- 0.58).</p><p><b>CONCLUSION</b>Smoking cessation might decrease the risk of lung cancer among male smokers. The risk of lung cancer was lower among the smoking quitters with longer history of smoking, older age, and longer years of quitting smoking.</p>

Effect of Shensong Yangxin Capsule on Cardiac Remodelling of Myocardial Infarction Mouse Model / 医药导报

Objective To investigate the effect of Shensong Yangxin capsule on cardiac remodelling of myocardial infarction mouse model and the possible molecular mechanisms. Methods Adult male C57BL/6J mice were divided into sham operation group(n=10), model control group(n=20)and Shensong Yangxin group(n=20)according to random number table. Left anterior descending branch of coronary artery was ligated to establish myocardic infarction model in the model control group and Shensong Yangxin group. From the 2nd day after the surgery, Shensong Yangxin ( 400 mg . kg-1 ) was intragastrically administered, and the death rate of the mice was observed.Four weeks after the surgery, echocardiography was used to measure the cardiac function;myocardiac infarction area was detected by pathological staining;the expression levels of cardiac remodelling markers and extracellular matrix proteins were detected by RT-PCR. The possible molecular mechanisms were screened by Western blotting. Results As compared with the model control group, Shensong Yangxin significantly reduced the mortality after myocardial infarction in mice(P<0.05), as well as the myocardial infarct size(P<0.05).The mRNA expression levels of cardiac remodelling markers ANP, BNP, and β-MHC and the extracellular matrix proteins(collagenⅠ, collagen Ⅲ, CTGF, TGFβ) decreased significantly in the Shensong Yangxin group as compared with the model control group. Western blotting showed that Shensong Yangxin significantly decreased activation of smad3, and reduced expression level of smad4. Conclusion Shensong Yangxin attenuates cardiac remodelling after myocardial infarction and the mechanism may be related with blockage of smad signaling pathway.

The mediating effects of perceived social support between clinicians' work pressure and compassion fatigue / 中华行为医学与脑科学杂志

Objective To explore the relationship among clinicians' work pressure,perceived social support and compassion fatigue,and to provide a new prospective for the localization studying of intervention and treatment to compassion fatigue.Methods Data of scale for occupational stressors on clinician,perceived social support scale and professional quality of life scale were collected from a sample of 533 clinicians and analyzed with structural equation modeling to study the relationship among clinicians' work pressure,perceived social support and compassion fatigue.Results (1)Work pressure(2.40±0.45),burnout (2.14±0.54) and secondary traumatic stress(1.93±0.60) scores of the clinicians with high perceived social support were significantly lower than that of the clinicians with low perceived social support (2.78±3.67,2.73± 0.59,2.32±0.71;t=7.68,-9.44,8.77,5.07;P＜0.01).Compassion satisfaction scores (4.15±0.63) of the clinicians with high perceived social support were significantly higher than that of the clinicians with low perceived social support (3.40±0.71,t =-9.44,P＜0.01).(2) According to relevant results,work pressure was significantly negative correlation with both perceived social support (r=-0.34,P＜0.01) and compassion satisfaction (r=-0.44,P＜0.01),and significantly positive correlation with both burnout (r=0.69,P＜0.01) and secondary traumatic stress(r=0.53,P＜0.01);while perceived social support was significantly positive correlation with compassion satisfaction (r=0.42,P＜0.01),and significantly negative correlation with burnout (r=-0.40,P＜0.01) and secondary traumatic stress(r=-0.26,P＜0.01).(3) According to the results of structural equation modeling,perceived social support played a partly mediating role in the effect of work pressure toward compassion satisfaction and fatigue with the intermediary effect of 55.4％ and 12.5％.Conclusion Perceived social support plays a mediation role between work pressure and compassion fatigue for clinicians,and better social support of the clinician is beneficial to clinicians mental health level.

Effect of maximum blood pressure when discharged from the hospital on the prognosis among patients with acute ischemic stroke / 中华流行病学杂志

Objective To investigate the relationship between maximum blood pressure and the prognosis after discharged from the hospital,among patients with ischemic stroke.Methods A cohort study was conducted which including 471 cases of ischemic stroke patients that were collected from February 2014 to December 2014 at the Second Affiliated Hospital of Harbin Medical University.Values of everyday blood pressure were measured on each patient at the first six days after admitted to the hospital.Maximum blood pressure value of the 6 days was taken as an indicator of the blood pressure levels.The ability on daily living was measured by the modified Rankin score (mRs).Data were analyzed by Chi-square test,t test and multivariate logistic regression analysis.Results Confounding factors would include age,gender,culture,physical activity,income,smoking,alcohol,hypertension,diabetes,coronary heart disease,stroke history,hospitalization mrs,lipid parameters,homocysteine and blood sugar and were adjusted.Results from multivariate logistic regression analysis showed that the maximum SBP was associated with adverse outcomes.Compared with 140-159 mmHg for SBP,OR(95％CI) was 2.51 (1.30-4.85) for 160-179 mmHg,OR (95％ CI) was 2.68 (1.27-5.65) for those pressure levels higher than 180 mmHg,after multiple factors were adjusted.Compared with 90-99 mmHg for DBP,OR(95％CI) was 1.92 (1.00-3.67) for 100-109 mmHg,OR (95％ CI) was 2.78 (1.35-5.69) for the ones higher than 110 mmHg.Conclusion Maximum blood pressure during hospitalization might be associated with adverse outcome of ischemic stroke patients.

Impact the variability of blood pressure on the outcome of ischemic stroke patients upon discharge from the hospital / 中华流行病学杂志

Objective To explore the relationship between blood pressure variability and worsening functional outcomes of patients upon discharge from the hospitals.Methods The study cohort consisted of 404 patients who presented to Second Affiliated Hospital of Harbin Medical University with ischemic stroke during March 2012-March 2013.Systolic BP and diastolic BP were measured for each patient from admission to the fifth day and coefficient of variation blood pressure calculated.Disability at discharge was measured by the modified Rankin score(mRs).Chi-square test,t-test and multivariate logistic regression analysis were performed.Results After adjustment for potential confounding factors including age,sex,activity,smoking,alcohol intake,BMI,heart rate,hypertension,diabetes mellitus,stroke history,lipid parameters,homocysteine and FPG,results from the multivariate logistic regression analysis showed that when DBP variability was greater than 9,it was associated with a significantly worse functional outcome at hospital discharge compared with those less than 9,with the odds ratio as 1.70(95％CI:1.02-2.84).When comparing the ones that DBP variability more than 10 with the ones less than 10,the odds ratio was 1.86 (95％CI:1.11-3.13).However,there was no significant association seen between SBP variability and the worse functional outcome at hospital discharge.Conclusion Blood pressure variability might be associated with ischemic stroke outcome at hospital discharge but needed more evidence to approve.

Suicide exposure and its modulatory effects on relations between life events and suicide risk in Chinese college students / 南方医科大学学报

<p><b>OBJECTIVE</b>To explore the incidence of suicide exposure and its association with suicide risk in Chinese college students, and study the modulatory effects of suicide exposure on the relations between life events and suicide risks.</p><p><b>METHODS</b>A total of 8202 college students from 12 Chinese colleges and universities in mainland China completed a cross-sectional survey that included suicidal behaviors questionnaire-revised (SBQ-R), Adolescent Self-Rating Life Events Check List (ASLEC), suicide exposure questionnaire, social and demographic characteristics questionnaire.</p><p><b>RESULTS</b>The incidence of exposure to suicide events involving close relatives and acquaintances were 3.9% and 11.8% among sampled Chinese college students, respectively. Students exposed to suicide events involving close relatives had significantly higher total SBQ-R scores than those who did not (5.51∓2.44 vs 4.68∓2.11, P<0.01), and suicide events of acquaintances were also associated with significantly increased total SBQ-R scores (5.51∓2.44 vs 4.68∓2.11, P<0.01); these suicides events all contributed to significantly increased rates of suicidal ideation, suicide plans and suicide attempts in the college students (P<0.05). The life events showed a significant positive correlation with suicide risks (0.11≤r≤0.26, P<0.01). The interactions of exposure to suicide events involving close relatives and acquaintances and the interactions of life events and suicide of close relatives for suicide risk were not significant (P>0.05), but exposure to acquaintance suicide events moderated the effects of life events on suicide risk (P<0.01), and the college students with a high level of life events and history of acquaintance suicide had the highest risk for suicide.</p><p><b>CONCLUSION</b>In Chinese college students, the risk of suicide is closely associated with exposure to suicide events and life events, and exposure to suicide events involving acquaintances can modulate the effects of life events on suicide risk.</p>

Moderating or mediating effects of life-meaning between optimism and suicide risk in undergraduate / 中华行为医学与脑科学杂志

Objective To explore the moderating or mediating effects of life-meaning between optimism and suicide risk in undergraduates.Methods A total of 1310 college students from one Chinese university completed a survey that included Suicidal Behaviors Questionnaire-Revised (SBQ-R),the Life Orientation Test-Revised (LOT-R) and the Chinese meaning in life questionnaire (C-MLQ).Results The total scores of SBQ-R,LOT-R and C-MLQ of undergraduate were (5.04 ± 2.28),(11.22 ± 2.07) and (37.22 ± 5.22),respectively.Optimism had significant negative correlation with suicide risk (r =-0.22,P ＜ 0.01),and positive correlation with life-meaning (r=0.28,P＜0.01).Life-meaning had significant negative correlation with suicide risk (r=-0.18,P＜0.01).The life-meaning's moderating effects between optimism and suicide risk were not significant(P ＞ 0.05),while the relationship between optimism and suicide risk was mediated by life-meaning,and the mediating effect was 0.07,which accounted for 17％ of the total effects.Conclusion Life-meaning doesnt morderating effect,but partially mediates the relationship between optimism and suicide risk.

A controlled study of cortisol, thyroid hormone and autonomic function in anxiety disorder / 中华行为医学与脑科学杂志

ObjectiveTo investigate the features of the cortisol ( COR),thyroid hormone and autonomic function of anxiety disorder,and to observe the relationships between clinical subtypes,insomnia,gender factors and the neuroendocrine and autonomic function.Methods60 anxiety disorder patients and 60 healthy controls were randomly selected from a three-grade class A hospital over the same period.Blood at 8:00am to test the plasma COR,T3,T4,TSH level and examined the heart rate variability (HRV) on the same day,the anxiety disorder patients also finish the self-rating anxiety scale (SAS).ResultsThe plasma COR,TSH level and LF/HF index were significantly higher( (531.58 ± 218.59 ) nmol/L,P＜ 0.0l ; (3.50 ± 1.35 ) MIU/L,P＜ 0.05 ;3.87 ± 3.37,P＜0.0l ),while the SDNN,LF,HF index were significantly lower in anxiety disorder than that in the control group (27.34±13.13,P＜0.01;338.72 ±396.34,P＜0.01;135.77 ±149.95,P＜0.01).The plasma COR,TSH level and LF/HF index were significantly higher(P ＜ 0.05,P＜0.01,P＜0.01 ),while the SDNN and HF index were significantly lower in panic disorder than that in the generalized anxiety disorder (P ＜ 0.01 ).The plasma COR,TSH level and LF/HF index were significantly higher,while the SDNN,LF,HF index were significantly lower in panic disorder than that in the control group (P＜0.01 ).The plasma COR was significantly higher,while the SDNN and HF index were significantly lower in generalized anxiety disorder than that of the control group (P＜0.01 ).The plasma COR level and LF/HF index were significantly higher (P＜0.01,P＜0.05),while the SDNN,LF,HF index were significantly lower in anxiety disorder with or without insomnia than that in the control group (P＜ 0.01 ).The plasma TSH level was significantly higher in anxiety disorder with insomnia than that in the control group (P＜ 0.05 ).There were no significant difference of the neuroendocrine and autonomic function between anxiety disorder with or without insomnia (P ＞ 0.05 ).The plasma COR,TSH level were significantly higher,while the SDNN,LF,HF index were significantly lower in the female group than that in the male group (P＜0.01).The total SAS scores were significantly positively correhted with plasma COR levels,and was significantly negatively correlated with SDNN,HF index in the anxiety group.ConclusionThere are neuroendocrine and autonomic nervous system dysfunctions in anxiety disorder,and these dysfunctions are related with clinical subtypes,insomnia,and gender.

Relationship between perfectionism and procrastination among medica students / 中华行为医学与脑科学杂志

Objective To explore the relationship between perfectionism and procrastination among medical students.Methods 327 medical students of two medical universities in Guangzhou were investigated by the chinese Frost Multidimensional Perfectionism Scale and the Aitken Procrastination Inventory.Results Compared with ordinary college students, medical students got higher scores on CM (12.87 ± 5.017 vs 11.5 ± 4.9), PE ( 14.89 ± 4.603 vs 13.6 ± 5.1 ) and Negative Perfectionism (58.08 ± 12.716 vs 56.1 ± 12.4), but got lower scores on PS (18.00±4.679 vs 18.7 ±5.2).There is the significant negative correlation between OR and procrastination (P＜ 0.001 ).CM, DA, Negative Perfectionism score and procrastination have notable positive correlation (P＜0.01 ).The results of regression analysis show that OR and DA can predict procrastination (P＜0.01).Conclusions Compared with ordinary college students, the perfectionism among contemporary medical students is higher and high negative perfectionist behaves with more procrastination.

Epidemiological characteristics of metabolic syndrome and its correlation factors in Harbin / 中华内分泌代谢杂志

Objective To assess epidemiological characteristics of metabolic syndrome(MS)and its attributing factors in a resident sample aged over 35 living in both rural and urban areas of Harbin in Heilongjiang province.Methods A cross-over sectional and cluster sampling was carried out in 5 984 residents aged over 35 years living in the rural and urban areas of Harbin.Height,body mass,waist circumference,blood pressure,fasting blood glucose,triglyeeride,and high density lipoprotein cholesterol were determined.In this survey,the prevalence of MS and its attributing factors were analyzed by logistic regression model according to the diagnostic criteria of international diabetes federation in 2005.Results The prevalence of MS in this sample was 24.60%(male 22.49%,female 26.29%),and the standardized prevalence rate was 23.31%(male 22.12%,female 25.19%).Compared to female population,male participants showed a much lower prevalence;and compared to urban area population,rural participants showed a much lower prevalence(26.70% vs 20.05%,P<0.05).The prevalence of MS rose progressively with age in females.The individuals with MS presented increased body mass index,hyperglycemia,and hypertriglyceridemia.Gender,age,employment,education,smoking or drinking habit,and family history of hypertension were identified as maior risk factors of MS.Conclusion The prevalence of MS in a sample of residents aged over 35 in Harbin Was 24.60%.It becomes an public health problem requiring urgent attention for prevention and treatment.